Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School,Boston, MA, USA.
Neurology. 2012 Apr 10;78(15):1138-45. doi: 10.1212/WNL.0b013e31824f7fc4. Epub 2012 Apr 4.
To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing Parkinson disease (PD).
In the current analysis, we included 49,281 men in the Health Professional Follow-up Study and 80,336 women from the Nurses' Health Study. Five major sources of flavonoid-rich foods (tea, berry fruits, apples, red wine, and orange/orange juice) were also examined. Flavonoid intake was assessed using an updated food composition database and a validated food frequency questionnaire.
We identified 805 participants (438 men and 367 women) who developed PD during 20-22 years of follow-up. In men, after adjusting for multiple confounders, participants in the highest quintile of total flavonoids had a 40%lower PD risk than those in the lowest quintile (hazard ratio [HR] = 0.60; 95% confidence interval 0.43, 0.83; p trend = 0.001). No significant relationship was observed in women (p trend = 0.62) or in pooled analyses (p trend = 0.23). In the pooled analyses for the subclasses, intakes of anthocyanins and a rich dietary source, berries, were significantly associated with a lower PD risk (HR comparing 2 extreme intake quintiles were 0.76 for anthocyanins and 0.77 for berries, respectively; p trend < 0.02 for both).
Our findings suggest that intake of some flavonoids may reduce PD risk, particularly in men, but a protective effect of other constituents of plant foods cannot be excluded.
前瞻性研究总类黄酮及其亚类（黄烷酮、花青素、黄烷醇、黄酮醇、黄酮和聚合物）的摄入量是否与较低的帕金森病（PD）发病风险相关。
在当前分析中，我们纳入了健康专业人员随访研究中的 49281 名男性和护士健康研究中的 80336 名女性。还研究了五种富含类黄酮的食物来源（茶、浆果、苹果、红酒和橙汁/橘子汁）。类黄酮的摄入量通过更新的食物成分数据库和经过验证的食物频率问卷进行评估。
我们在 20-22 年的随访中发现了 805 名（438 名男性和 367 名女性）发生 PD 的参与者。在男性中，调整了多种混杂因素后，总类黄酮摄入量最高五分位的参与者 PD 发病风险比最低五分位的参与者低 40%（风险比 [HR] = 0.60；95%置信区间 0.43，0.83；p 趋势= 0.001）。在女性（p 趋势= 0.62）或汇总分析中（p 趋势= 0.23）未观察到显著相关性。在亚类别的汇总分析中，花青素和富含类黄酮的食物来源浆果的摄入量与较低的 PD 风险显著相关（比较两个极端摄入量五分位数的 HR 分别为 0.76 对于花青素和 0.77 对于浆果，p 趋势均<0.02）。
我们的研究结果表明，一些类黄酮的摄入可能会降低 PD 风险，尤其是男性，但不能排除植物性食物其他成分的保护作用。
