Novartis Vaccines and Diagnostics, 53100 Siena, Italy.
Sci Transl Med. 2012 Apr 4;4(128):128cm4. doi: 10.1126/scitranslmed.3003826.
Scientists sit poised at a singular moment in the history of vaccine research. Genomics and systems biology have fueled advances in our understanding of human immunology. Together with adjuvant development and structure-based design of immunogens, these next-generation technologies are transforming the field of vaccinology and shaping the future of medicine. However, the sophisticated science behind the development of modern vaccines and the resulting knotty ethical issues have become so complex that scientists and policy-makers need a new model for vaccine research. The European Commission-sponsored Advanced Immunization Technologies project--ADITEC--brings together some of the leading laboratories in the field to tackle the problems that no lab can tackle in isolation.
科学家们正处于疫苗研究历史上的一个独特时刻。基因组学和系统生物学推动了我们对人类免疫学的理解的进步。与佐剂开发和基于结构的免疫原设计一起，这些下一代技术正在改变疫苗学领域，并塑造医学的未来。然而，现代疫苗开发背后的复杂科学以及由此产生的棘手伦理问题变得如此复杂，以至于科学家和政策制定者需要一种新的疫苗研究模式。欧盟委员会资助的高级免疫技术项目--ADITEC--汇集了该领域的一些领先实验室，共同解决任何一个实验室都无法单独解决的问题。
