State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China.
Protein Cell. 2012 Apr;3(4):305-10. doi: 10.1007/s13238-012-2913-9. Epub 2012 Apr 10.
The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death. Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis. Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis, and the crosstalk between the Hippo signaling pathway and other major signaling pathways, i.e. Wnt, Notch and Jak/Stat signaling pathways in intestinal compartment.
Hippo 通路通过抑制细胞增殖和促进细胞死亡来控制器官大小，在这一过程中发挥着关键作用。最近的研究表明，该通路参与了肠道再生和肿瘤发生的过程。在这里，我们总结了 Hippo 信号通路在肠道稳态、再生和肿瘤发生中的功能的最新研究，以及 Hippo 信号通路与其他主要信号通路（即 Wnt、Notch 和 Jak/Stat 信号通路）在肠道中的相互作用。
