Department of Materials Engineering, Monash University, Victoria, Australia.
J Biomater Appl. 2012 Nov;27(4):369-90. doi: 10.1177/0885328212443297. Epub 2012 Apr 5.
Patients who experience injury to the central or peripheral nervous systems invariably suffer from a range of dysfunctions due to the limited ability for repair and reconstruction of damaged neural tissue. Whilst some treatment strategies can provide symptomatic improvement of motor and cognitive function, they fail to repair the injured circuits and rarely offer long-term disease modification. To this end, the biological molecules, used in combination with neural tissue engineering scaffolds, may provide feasible means to repair damaged neural pathways. This review will focus on three promising classes of neural tissue engineering scaffolds, namely hydrogels, electrospun nanofibres and self-assembling peptides. Additionally, the importance and methods for presenting biologically relevant molecules such as, neurotrophins, extracellular matrix proteins and protein-derived sequences that promote neuronal survival, proliferation and neurite outgrowth into the lesion will be discussed.
患者中枢或周围神经系统损伤后，由于受损神经组织的修复和重建能力有限，不可避免地会出现多种功能障碍。虽然一些治疗策略可以改善运动和认知功能的症状，但它们无法修复受损的回路，很少能提供长期的疾病改善。为此，与神经组织工程支架结合使用的生物分子可能为修复受损的神经通路提供可行的方法。本综述将重点介绍三种有前途的神经组织工程支架，即水凝胶、静电纺纳米纤维和自组装肽。此外，还将讨论将生物相关分子（如神经营养因子、细胞外基质蛋白和促进神经元存活、增殖和神经突生长的蛋白衍生序列）递送到病变部位的重要性和方法。
