Tillmaand Emily G, Sweedler Jonathan V
Department of Chemistry, the Neuroscience Program and the Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Microphysiol Syst. 2018 Jun;2. doi: 10.21037/mps.2018.05.01. Epub 2018 Jun 11.
Microphysiological systems, often referred to as "organs-on-chips", are platforms designed to model the spatial, chemical, structural, and physiological elements of cellular environments. They enhance the evaluation of complex engineered biological systems and are a step between traditional cell culture and experimentation. As neurochemists and measurement scientists studying the molecules involved in intercellular communication in the nervous system, we focus here on recent advances in neuroscience using microneurological systems and their potential to interface with mass spectrometry. We discuss a number of examples - microfluidic devices, spheroid cultures, hydrogels, scaffolds, and fibers - highlighting those that would benefit from mass spectrometric technologies to obtain improved chemical information.
微生理系统，通常被称为“芯片上的器官”，是旨在模拟细胞环境的空间、化学、结构和生理要素的平台。它们增强了对复杂工程生物系统的评估，是传统细胞培养与实验之间的一个阶段。作为研究神经系统中细胞间通讯所涉及分子的神经化学家与测量科学家，我们在此聚焦于使用微神经学系统的神经科学最新进展及其与质谱联用的潜力。我们讨论了一些实例——微流控装置、球体培养物、水凝胶、支架和纤维——重点介绍那些将受益于质谱技术以获取更完善化学信息的实例。
