School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Nanomedicine (Lond). 2013 May;8(5):823-47. doi: 10.2217/nnm.13.65.
Tissue engineered therapies are emerging as solutions to several of the medical challenges facing aging societies. To this end, a fundamental research goal is the development of novel biocompatible materials and scaffolds. Self-assembling peptides are materials that have undergone rapid development in the last two decades and they hold promise in meeting some of these challenges. Using amino acids as building blocks enables a great versatility to be incorporated into the structures that peptides form, their physical properties and their interactions with biological systems. This review discusses several classes of short self-assembling sequences, explaining the principles that drive their self-assembly into structures with nanoscale ordering, and highlighting in vitro and in vivo studies that demonstrate the potential of these materials as novel soft tissue engineering scaffolds.
组织工程疗法作为应对老龄化社会面临的若干医学挑战的解决方案而崭露头角。为此，一个基础研究目标是开发新型生物相容性材料和支架。自组装肽是过去二十年中发展迅速的材料，它们有望应对其中一些挑战。使用氨基酸作为构建块可以极大地提高将各种特性纳入到肽形成的结构、其物理特性及其与生物系统相互作用的能力。本文综述了几类短自组装序列，解释了驱动它们自组装成具有纳米级有序结构的原理，并重点介绍了体外和体内研究，这些研究表明这些材料作为新型软组织工程支架的潜力。
