Meng Xin, Wang Xiaofeng, Jiang Yongchao, Zhang Bo, Li Kun, Li Qian
School of Mechanics Science and Engineering, National Center for International Research of Micro-nano Molding Technology, Zhengzhou University Zhengzhou China
People's Hospital of Henan Province, Zhengzhou University Zhengzhou China
RSC Adv. 2019 Jul 9;9(37):21258-21264. doi: 10.1039/c9ra04529e. eCollection 2019 Jul 5.
The suture retention strength of artificial vascular grafts is a key mechanical property that affects the function of the grafts. Different from the conventional method of testing the suture retention strength, this study simulated the actual suturing state of vascular scaffolds approximately and investigated the effect of graft type, graft wall thickness, and number of stitches on the suture retention strength of poly(l-lactide--ε-caprolactone) P(LLA-CL) vascular grafts. The results showed that the P(LLA-CL) tissue-engineered vascular scaffolds have excellent suture performance and, when the graft wall thickness is greater than 0.24 mm, the suture retention strength will meet the vascular transplantation standard. Under the same conditions, the greater the number of stitches, the more uniform the force of the anastomosis and then the greater the suture retention strength. This experiment provides a more comprehensive and accurate suture retention strength value for the application of P(LLA-CL) tissue engineered vascular grafts, which helps to guide the further optimization of tissue-engineered vascular grafts to meet specific mechanical performance requirements.
人工血管移植物的缝线保留强度是影响移植物功能的关键力学性能。与测试缝线保留强度的传统方法不同，本研究近似模拟了血管支架的实际缝合状态，并研究了移植物类型、移植物壁厚和缝合针数对聚（L-丙交酯-ε-己内酯）P（LLA-CL）血管移植物缝线保留强度的影响。结果表明，P（LLA-CL）组织工程血管支架具有优异的缝合性能，当移植物壁厚大于0.24mm时，缝线保留强度将符合血管移植标准。在相同条件下，缝合针数越多，吻合处受力越均匀，缝线保留强度越大。本实验为P（LLA-CL）组织工程血管移植物的应用提供了更全面、准确的缝线保留强度值，有助于指导组织工程血管移植物的进一步优化，以满足特定的力学性能要求。
