短程齐多夫定对单次应用奈韦拉平女性中 HIV-1 对奈韦拉平耐药性选择的影响。
Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine.
机构信息
University of Washington, Seattle, Washington, USA.
出版信息
J Infect Dis. 2012 Jun 15;205(12):1811-5. doi: 10.1093/infdis/jis282. Epub 2012 Apr 5.
Abstract
Single-dose nevirapine (sdNVP) given to prevent mother-to-child-transmission of HIV-1 selects NVP-resistance. Short-course zidovudine (ZDV) was hypothesized to lower rates of NVP-resistance. HIV-1 infected pregnant women administered sdNVP with or without short-course ZDV were assessed for HIV-1 mutations (K103N, Y181C, G190A, and V106M) prior to delivery and postpartum. Postpartum NVP-resistance was lower among 31 taking ZDV+sdNVP compared to 33 taking only sdNVP (35.5% vs. 72.7%; χ2 P = .003). NVP mutants decayed to <2% in 24/35 (68.6%) at a median 6 months postpartum, with no differences based on ZDV use (logrank P = .99). Short-course ZDV was associated with reduced NVP-resistance mutations among women taking sdNVP.
摘要
单剂量奈韦拉平（sdNVP）用于预防 HIV-1 的母婴传播会选择出对 NVP 的耐药性。短程齐多夫定（ZDV）被假设可以降低 NVP 耐药率。对接受 sdNVP 加或不加短程 ZDV 的 HIV-1 感染孕妇在分娩前和产后进行 HIV-1 突变（K103N、Y181C、G190A 和 V106M）评估。与仅接受 sdNVP 的 33 名孕妇相比，接受 ZDV+sdNVP 的 31 名孕妇的产后 NVP 耐药率较低（35.5% vs. 72.7%；χ2 P =.003）。在产后 6 个月时，35 名患者中有 24 名（68.6%）的 NVP 突变体衰减至<2%，ZDV 的使用没有差异（对数秩检验 P =.99）。对于接受 sdNVP 的妇女，短程 ZDV 与减少 NVP 耐药性突变有关。
相似文献
1
Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine.短程齐多夫定对单次应用奈韦拉平女性中 HIV-1 对奈韦拉平耐药性选择的影响。
J Infect Dis. 2012 Jun 15;205(12):1811-5. doi: 10.1093/infdis/jis282. Epub 2012 Apr 5.
2
Lower risk of resistance after short-course HAART compared with zidovudine/single-dose nevirapine used for prevention of HIV-1 mother-to-child transmission.与用于预防HIV-1母婴传播的齐多夫定/单剂量奈韦拉平相比，短疗程高效抗逆转录病毒疗法（HAART）后耐药风险更低。
J Acquir Immune Defic Syndr. 2009 Aug 15;51(5):522-9. doi: 10.1097/QAI.0b013e3181aa8a22.
3
A post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum single-dose nevirapine to prevent mother-to- child HIV-1 transmission.产后单剂量替诺福韦酯/恩曲他滨不能预防在产前接受齐多夫定及产时接受单剂量奈韦拉平以预防母婴HIV-1传播的女性中出现非核苷类逆转录酶抑制剂耐药。
J Med Virol. 2015 Oct;87(10):1662-7. doi: 10.1002/jmv.24220. Epub 2015 May 4.
4
Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission: a randomized clinical trial.短程 AZT 加 3TC 降低奈韦拉平耐药性预防母婴 HIV 传播的疗效：一项随机临床试验。
PLoS Med. 2009 Oct;6(10):e1000172. doi: 10.1371/journal.pmed.1000172. Epub 2009 Oct 27.
5
Maternal 12-month response to antiretroviral therapy following prevention of mother-to-child transmission of HIV type 1, Ivory Coast, 2003-2006.2003 - 2006年，科特迪瓦，预防1型艾滋病毒母婴传播后母亲接受抗逆转录病毒治疗的12个月反应情况
Clin Infect Dis. 2008 Feb 15;46(4):611-21. doi: 10.1086/526780.
6
Greater suppression of nevirapine resistance with 21- vs 7-day antiretroviral regimens after intrapartum single-dose nevirapine for prevention of mother-to-child transmission of HIV.与 7 天疗程相比，在预防 HIV 母婴传播的单剂量产后奈韦拉平方案中，21 天抗逆转录病毒方案对奈韦拉平耐药性的抑制作用更强。
Clin Infect Dis. 2013 Apr;56(7):1044-51. doi: 10.1093/cid/cis1219. Epub 2013 Jan 8.
7
Analysis of nevirapine resistance in HIV-infected infants who received extended nevirapine or nevirapine/zidovudine prophylaxis.分析接受扩展奈韦拉平或奈韦拉平/齐多夫定预防的 HIV 感染婴儿的奈韦拉平耐药情况。
AIDS. 2011 Apr 24;25(7):911-7. doi: 10.1097/QAD.0b013e328344fedc.
8
Efficacy and safety of 1-month postpartum zidovudine-didanosine to prevent HIV-resistance mutations after intrapartum single-dose nevirapine.1 个月 postpartum 齐多夫定-去羟肌苷预防单剂量奈韦拉平分娩后 HIV 耐药突变的疗效和安全性。
Clin Infect Dis. 2010 Mar 15;50(6):898-908. doi: 10.1086/650745.
9
Randomized noninferiority trial of two maternal single-dose nevirapine-sparing regimens to prevent perinatal HIV in Thailand.泰国两种孕产妇单剂量节省奈韦拉平方案预防围产期艾滋病毒的随机非劣效性试验。
AIDS. 2015 Nov 28;29(18):2497-507. doi: 10.1097/QAD.0000000000000865.
10
Resistance mutations in HIV-1 infected pregnant women and their infants receiving antiretrovirals to prevent HIV-1 vertical transmission in China.中国接受抗逆转录病毒药物以预防HIV-1垂直传播的HIV-1感染孕妇及其婴儿中的耐药性突变
Int J STD AIDS. 2009 Apr;20(4):249-54. doi: 10.1258/ijsa.2008.008480.
引用本文的文献
1
Correlates of HIV detection among breastfeeding postpartum Kenyan women eligible under Option B.肯尼亚符合 B 方案的哺乳期产后妇女中 HIV 检测的相关因素。
PLoS One. 2019 May 31;14(5):e0216252. doi: 10.1371/journal.pone.0216252. eCollection 2019.
2
Minority and majority pretreatment HIV-1 drug resistance associated with failure of first-line nonnucleoside reverse-transcriptase inhibitor antiretroviral therapy in Kenyan women.肯尼亚女性中，一线非核苷类逆转录酶抑制剂抗逆转录病毒治疗失败与治疗前 HIV-1 耐药的少数族裔和多数族裔相关。
AIDS. 2019 May 1;33(6):941-951. doi: 10.1097/QAD.0000000000002134.
3
Nevirapine-Resistant HIV-1 DNA in Breast Milk After Single-Dose Nevirapine With or Without Zidovudine for Prevention of Mother-to-Child Transmission.单剂量奈韦拉平联合或不联合齐多夫定预防母婴传播后母乳中耐奈韦拉平的HIV-1 DNA
J Pediatric Infect Dis Soc. 2012 Sep;1(3):244-9. doi: 10.1093/jpids/pis065. Epub 2012 Jul 3.
4
Impact of antiretroviral drugs in pregnant women and their children in Africa: HIV resistance and treatment outcomes.抗逆转录病毒药物对非洲孕妇及其儿童的影响：HIV 耐药性和治疗结局。
J Infect Dis. 2013 Jun 15;207 Suppl 2(Suppl 2):S93-100. doi: 10.1093/infdis/jit110.
5
Clinical implications of HIV-1 minority variants.HIV-1 少数变异体的临床意义。
Clin Infect Dis. 2013 Jun;56(11):1667-74. doi: 10.1093/cid/cit125. Epub 2013 Feb 27.
本文引用的文献
1
Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi.在马拉维，围产期单次应用奈韦拉平基础上加用 7 天齐多夫定和拉米夫定，可有效降低感染 HIV 的母亲产后的奈韦拉平耐药性。
J Acquir Immune Defic Syndr. 2010 Aug;54(5):515-23. doi: 10.1097/qai.0b013e3181e3a70e.
2
Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine.单剂量奈韦拉平治疗婴儿时，HIV-1 感染时间与奈韦拉平耐药的关系。
Clin Infect Dis. 2010 May 15;50(10):1405-14. doi: 10.1086/652151.
3
Association between detection of HIV-1 DNA resistance mutations by a sensitive assay at initiation of antiretroviral therapy and virologic failure.在开始抗逆转录病毒治疗时，通过敏感检测方法检测到 HIV-1 DNA 耐药突变与病毒学失败的关联。
Clin Infect Dis. 2010 May 15;50(10):1397-404. doi: 10.1086/652148.
4
Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission: a randomized clinical trial.短程 AZT 加 3TC 降低奈韦拉平耐药性预防母婴 HIV 传播的疗效：一项随机临床试验。
PLoS Med. 2009 Oct;6(10):e1000172. doi: 10.1371/journal.pmed.1000172. Epub 2009 Oct 27.
5
Lower risk of resistance after short-course HAART compared with zidovudine/single-dose nevirapine used for prevention of HIV-1 mother-to-child transmission.与用于预防HIV-1母婴传播的齐多夫定/单剂量奈韦拉平相比，短疗程高效抗逆转录病毒疗法（HAART）后耐药风险更低。
J Acquir Immune Defic Syndr. 2009 Aug 15;51(5):522-9. doi: 10.1097/QAI.0b013e3181aa8a22.
6
Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa.齐多夫定与奈韦拉平联合用于预防HIV母婴传播可降低南非西开普省母亲群体中的奈韦拉平耐药性。
J Med Virol. 2008 Jun;80(6):942-6. doi: 10.1002/jmv.21157.
7
Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial.用伐昔洛韦抑制单纯疱疹病毒可降低HIV-1/HSV-2血清阳性男性的直肠和血浆HIV-1水平：一项随机、双盲、安慰剂对照的交叉试验。
J Infect Dis. 2007 Nov 15;196(10):1500-8. doi: 10.1086/522523. Epub 2007 Oct 31.
8
Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana.在博茨瓦纳，作为预防母婴传播艾滋病毒抗逆转录病毒策略的一部分，母亲单剂量奈韦拉平与安慰剂的对比研究。
AIDS. 2006 Jun 12;20(9):1281-8. doi: 10.1097/01.aids.0000232236.26630.35.
9
Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission.单剂量奈韦拉平治疗预防母婴HIV-1传播后，女性体内耐奈韦拉平HIV-1的持续存在情况。
Proc Natl Acad Sci U S A. 2006 May 2;103(18):7094-9. doi: 10.1073/pnas.0602033103. Epub 2006 Apr 25.
10
Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy.分娩期暴露于奈韦拉平及随后母亲对基于奈韦拉平的抗逆转录病毒疗法的反应。
N Engl J Med. 2004 Jul 15;351(3):229-40. doi: 10.1056/NEJMoa041305. Epub 2004 Jul 9.
Zotero 插件