单剂量奈韦拉平联合或不联合齐多夫定预防母婴传播后母乳中耐奈韦拉平的HIV-1 DNA
Nevirapine-Resistant HIV-1 DNA in Breast Milk After Single-Dose Nevirapine With or Without Zidovudine for Prevention of Mother-to-Child Transmission.
作者信息
Gantt Soren, Payant Rachel, Carlsson Jacquelyn, Micek Mark A, Blanco Ana Judith, Beck Ingrid A, Matunha Laurinda, Montoya Pablo, Matediana Eduardo, Gloyd Stephen, Frenkel Lisa M
机构信息
Departments of Pediatrics Seattle Children's Hospital Research Institute, Center for Childhood Infections.
Seattle Children's Hospital Research Institute, Center for Childhood Infections.
出版信息
J Pediatric Infect Dis Soc. 2012 Sep;1(3):244-9. doi: 10.1093/jpids/pis065. Epub 2012 Jul 3.
Abstract
Among 30 human immunodeficiency virus type 1 (HIV-1)-infected women who received single-dose nevirapine (NVP), 17 (57%) had NVP-resistant HIV-1 detected in breast milk. NVP resistance in breast milk persisted for at least 8 months postpartum and was apparently transmitted to at least 1 infant. NVP resistance was detected less often in women who also received zidovudine.
摘要
在30名接受单剂量奈韦拉平（NVP）治疗的人类免疫缺陷病毒1型（HIV-1）感染女性中，17名（57%）女性的母乳中检测出对NVP耐药的HIV-1。母乳中的NVP耐药性在产后至少持续了8个月，并且显然传播给了至少1名婴儿。在同时接受齐多夫定治疗的女性中，NVP耐药性的检测频率较低。
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