Gastroenterology Section, Department of Internal Medicine, Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
World J Gastroenterol. 2012 Mar 28;18(12):1414-6. doi: 10.3748/wjg.v18.i12.1414.
Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding, hypertension, chronic heart failure, chronic renal failure and consumption of different drugs. We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain, nausea, melena and progressive reduction of hemoglobin index. Gastroduodenal endoscopy revealed erosions in the esophagus and stomach, with no active bleeding at the moment. In addition, the duodenal mucosa presented marked signs of melanosis; later confirmed by histopathological study. Even though PD is usually regarded as a benign condition, its pathogenesis and clinical significance is yet to be defined.
十二指肠假黑斑（PD）是一种罕见的十二指肠暗斑外观，与胃肠道出血、高血压、慢性心力衰竭、慢性肾衰竭和服用不同药物有关。我们报告了 4 例因上腹痛、恶心、黑便和血红蛋白指数逐渐下降而入住消化内科门诊的 PD 合并慢性肾衰竭患者。胃十二指肠内镜显示食管和胃有糜烂，但当时没有活动性出血。此外，十二指肠黏膜有明显的黑斑征；后来通过组织病理学研究得到证实。尽管 PD 通常被认为是一种良性疾病，但它的发病机制和临床意义尚待确定。
