Pueblitz S, Squires R H, Timmons C F
Department of Pathology, Children's Medical Center of Dallas, Texas, USA.
Pediatr Pathol Lab Med. 1997 Jan-Feb;17(1):115-23.
Pseudomelanosis duodeni is rarely seen in children. It manifests endoscopically as peppery speckles in the duodenal mucosa. This pigment corresponds principally to accumulation of ferrous sulfide in macrophages within the lamina propria. We report the case of a 16-year-old boy with ectodermal dysplasia who underwent renal transplantation for vesicoureteral reflux and later developed epigastric pain. Endoscopic and pathologic findings in the duodenal mucosa were typical of pseudomelanosis duodeni. A review of the literature reveals shared clinical features among reported adult and pediatric cases, including chronic renal failure, use of antihypertensive medication and oral iron supplementation, and/or presence of gastric hemorrhage.
十二指肠假黑色素沉着症在儿童中罕见。内镜下表现为十二指肠黏膜上的胡椒样斑点。这种色素主要对应于固有层内巨噬细胞中硫化亚铁的积累。我们报告了一例16岁患有外胚层发育不良的男孩，因膀胱输尿管反流接受肾移植，后来出现上腹部疼痛。十二指肠黏膜的内镜和病理检查结果为十二指肠假黑色素沉着症的典型表现。文献回顾显示，已报道的成人和儿童病例具有共同的临床特征，包括慢性肾衰竭、使用抗高血压药物和口服铁补充剂，和/或存在胃出血。
