eL-Newihi H M, Lynch C A, Mihas A A
Division of Gastroenterology, Veterans Affairs Medical Center, Jackson, MS 39216, USA.
Am J Med Sci. 1995 Sep;310(3):111-4. doi: 10.1097/00000441-199531030-00005.
Two male patients with mild gastrointestinal bleeding had peculiar dark pigmentation of their duodenum on upper endoscopy. These pigmented lesions were still present 3 months after the original endoscopy and after resolution of all other mucosal lesions. Both patients had other medical problems, including hypertension. They have been on multiple antihypertensive medications for many years. Biopsies of these duodenal lesions showed the pigment to be present inside the macrophages found in the lamina propria and in between the epithelial cells. Electron microscopy revealed a lysosomal localization of this pigment. This melanin-like pigment proved to contain varying amounts of iron, sulfur, and calcium. This pigmentation is closely associated with systemic hypertension, even in the pediatric population.
两名患有轻度胃肠道出血的男性患者在上消化道内镜检查时十二指肠出现特殊的深色色素沉着。这些色素沉着病变在初次内镜检查后3个月以及所有其他黏膜病变消退后仍然存在。两名患者都有其他医疗问题，包括高血压。他们多年来一直在服用多种抗高血压药物。这些十二指肠病变的活检显示色素存在于固有层的巨噬细胞内以及上皮细胞之间。电子显微镜检查显示这种色素定位于溶酶体。这种类似黑色素的色素被证明含有不同量的铁、硫和钙。即使在儿科人群中，这种色素沉着也与系统性高血压密切相关。
