Rex D K, Jersild R A
Department of Medicine, Indiana University School of Medicine, Indianapolis.
Gastroenterology. 1988 Jul;95(1):177-82. doi: 10.1016/0016-5085(88)90308-3.
Pseudomelanosis duodeni is a rare condition in which dark pigment accumulates in macrophages located in the lamina propria of the duodenal mucosa. Three cases are reported here and the literature is reviewed. No clinical association can be found that points clearly to the underlying etiology. Electron probe x-ray microanalysis was used to study the pigment in macrophage granules in 2 of our patients and demonstrated high iron and sulfur content. Iron accumulation in ferritinlike particles was detected in absorptive cell lysosomes. A possible mechanism for the accumulation of absorbed iron by macrophages is considered.
十二指肠假黑色素沉着症是一种罕见的病症，其中深色色素在十二指肠粘膜固有层的巨噬细胞中积聚。本文报告了3例病例并对文献进行了综述。未发现能明确指向潜在病因的临床关联。我们对2例患者使用电子探针X射线微分析来研究巨噬细胞颗粒中的色素，结果显示铁和硫含量很高。在吸收细胞溶酶体中检测到铁在类铁蛋白颗粒中的积累。文中考虑了巨噬细胞吸收铁积累的一种可能机制。
