Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy.
ACS Nano. 2012 Apr 24;6(4):3080-91. doi: 10.1021/nn2048137. Epub 2012 Apr 11.
Iron oxide nanocrystals (IONCs) are appealing heat mediator nanoprobes in magnetic-mediated hyperthermia for cancer treatment. Here, specific absorption rate (SAR) values are reported for cube-shaped water-soluble IONCs prepared by a one-pot synthesis approach in a size range between 13 and 40 nm. The SAR values were determined as a function of frequency and magnetic field applied, also spanning technical conditions which are considered biomedically safe for patients. Among the different sizes tested, IONCs with an average diameter of 19 ± 3 nm had significant SAR values in clinical conditions and reached SAR values up to 2452 W/g(Fe) at 520 kHz and 29 kAm(-1), which is one of the highest values so far reported for IONCs. In vitro trials carried out on KB cancer cells treated with IONCs of 19 nm have shown efficient hyperthermia performance, with cell mortality of about 50% recorded when an equilibrium temperature of 43 °C was reached after 1 h of treatment.
氧化铁纳米晶体（IONC）作为一种热介质纳米探针，在用于癌症治疗的磁介导热疗中具有吸引力。本研究采用一锅合成法制备了尺寸在 13 至 40nm 之间的具有立方形状的水溶性 IONC，并报告了其比吸收率（SAR）值。SAR 值是作为频率和所施加磁场的函数来确定的，同时也涵盖了被认为对患者在医学上安全的技术条件。在所测试的不同尺寸中，平均直径为 19±3nm 的 IONC 在临床条件下具有显著的 SAR 值，并在 520kHz 和 29kAm-1 时达到高达 2452W/g(Fe)的 SAR 值，这是迄今为止报道的 IONC 的最高值之一。对用 19nm 的 IONC 处理的 KB 癌细胞进行的体外试验表明，其具有高效的热疗性能，在 1 小时的治疗后达到 43°C 的平衡温度时，记录到约 50%的细胞死亡率。
