地中海海绵 Spongia officinalis 的防御分泌物的粗提物及其馏分的抗惊厥和镇痛活性。
Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis.
机构信息
Laboratoire de biotechnologie et Valorisation de Bio Géo Ressources (LBVBGR) Institut Supérieur de Biotechnologie, ISBST BioTechPole Sidi Thabet Université Manouba, Ariana, 2020, Tunisie.
出版信息
Cancer Cell Int. 2012 Apr 11;12(1):15. doi: 10.1186/1475-2867-12-15.
Abstract
This study progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with anticonvulsant and analgesic activities. We investigated the efficacy of crude extract and its semi-purified fractions (F1-F3) of the defensive secretion from Spongia officinalis for their in vivo anticonvulsant activity using the pentylenetetrazole (PTZ) seizure model and analgesic activity using the writhing test in mice. Among the series the crude extract exhibited interesting analgesic activity in a dose dependent manner. Similarly the fraction F2 showed a partial protection of mice from PTZ-induced seizure and interesting analgesic activity in a dose dependent manner. The purification and the determination of chemical structure(s) of compound(s) of this active fraction are under investigation.
摘要
本研究旨在从地中海海绵 Spongia officinalis 中鉴定具有抗惊厥和镇痛活性的成分。我们研究了来自 Spongia officinalis 的防御分泌物的粗提物及其半纯化部分（F1-F3）在戊四唑（PTZ）惊厥模型中的体内抗惊厥活性和在小鼠扭体试验中的镇痛活性。在该系列中，粗提物表现出剂量依赖性的有趣镇痛活性。同样，F2 部分也显示出对 PTZ 诱导的惊厥有部分保护作用，并具有剂量依赖性的有趣镇痛活性。目前正在对该活性部分化合物的分离和化学结构的确定进行研究。
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