• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis.地中海海绵 Spongia officinalis 的防御分泌物的粗提物及其馏分的抗惊厥和镇痛活性。
Cancer Cell Int. 2012 Apr 11;12(1):15. doi: 10.1186/1475-2867-12-15.
2
Evaluation of antiproliferative and anti-inflammatory activities of methanol extract and its fractions from the Mediterranean sponge.评价地中海海绵甲醇提取物及其馏分的抗增殖和抗炎活性。
Cancer Cell Int. 2012 May 15;12(1):18. doi: 10.1186/1475-2867-12-18.
3
In vitro immunomodulatory activity and in vivo anti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red alga Laurencia obtusa.地中海红藻钝叶马尾藻的体外免疫调节活性及体内抗炎、镇痛和胃保护作用。
Pharm Biol. 2016 Nov;54(11):2486-2495. doi: 10.3109/13880209.2016.1160937. Epub 2016 Apr 20.
4
Anticonvulsant effect of Cicer arietinum seed in animal models of epilepsy: introduction of an active molecule with novel chemical structure.鹰嘴豆种子在癫痫动物模型中的抗惊厥作用：一种具有新型化学结构的活性分子的引入。
Iran Biomed J. 2015;19(1):45-50. doi: 10.6091/ibj.1391.2014.
5
Anticonvulsant Effects of Aerial Parts of Verbena officinalis Extract in Mice: Involvement of Benzodiazepine and Opioid Receptors.马鞭草地上部分提取物对小鼠的抗惊厥作用：苯二氮䓬受体和阿片受体的参与
J Evid Based Complementary Altern Med. 2017 Oct;22(4):632-636. doi: 10.1177/2156587217709930. Epub 2017 Jun 6.
6
Evaluation of the Anticonvulsant Activity of the Leaves of Glycyrrhiza glabra var. glandulifera Grown in Iran, as a Possible Renewable Source for Anticonvulsant Compounds.对生长在伊朗的腺果甘草叶片抗惊厥活性的评估，作为抗惊厥化合物可能的可再生来源。
Iran J Pharm Res. 2011 Winter;10(1):75-82.
7
Effect of 70% Ethanol Extract and its Solvent Fractions of (Jacq. Ex Willd.) against Pentylenetetrazole-Induced Seizure in Mice.（雅克奎因·埃克斯·威尔德）70%乙醇提取物及其溶剂分离物对戊四氮诱导的小鼠癫痫发作的影响。
Evid Based Complement Alternat Med. 2021 Jun 17;2021:6690965. doi: 10.1155/2021/6690965. eCollection 2021.
8
Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis.
Asian Pac J Trop Med. 2015 Aug;8(8):606-11. doi: 10.1016/j.apjtm.2015.07.019. Epub 2015 Jul 23.
9
Antinociceptive and anticonvulsant activities of hydroalcoholic extract of Jasminum grandiflorum (jasmine) leaves in experimental animals.大花茉莉叶水醇提取物在实验动物中的抗伤害感受和抗惊厥活性。
Pharmacognosy Res. 2013 Oct;5(4):286-90. doi: 10.4103/0974-8490.118813.
10
Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish).缬草烯酸和缬草提取物可延迟成年斑马鱼由戊四氮（PTZ）诱导的癫痫发作的起始时间。
BMC Complement Altern Med. 2015 Jul 14;15:228. doi: 10.1186/s12906-015-0731-3.

引用本文的文献

1
Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources.从地中海海绵来源分离的提取物和化合物的药理活性。
Pharmaceuticals (Basel). 2021 Dec 18;14(12):1329. doi: 10.3390/ph14121329.
2
Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi.斑马鱼鉴定法从海洋硅藻中发现抗癫痫核苷肌苷。
PLoS One. 2018 Apr 24;13(4):e0196195. doi: 10.1371/journal.pone.0196195. eCollection 2018.
3
The Role of Spongia sp. in the Discovery of Marine Lead Compounds.海绵属物种在海洋铅化合物发现中的作用。
Mar Drugs. 2016 Jul 23;14(8):139. doi: 10.3390/md14080139.
4
In vivo screening of essential oils of Skimmia laureola leaves for antinociceptive and antipyretic activity.对月桂茵芋叶精油进行体内抗伤害性感受和退热活性筛选。
Asian Pac J Trop Biomed. 2013 Mar;3(3):202-6. doi: 10.1016/S2221-1691(13)60050-7.

本文引用的文献

1
Inter- and intraspecific variations of bacterial communities associated with marine sponges from san juan island, washington.华盛顿圣胡安岛海洋海绵相关细菌群落的种间和种内变异
Appl Environ Microbiol. 2009 Jun;75(11):3513-21. doi: 10.1128/AEM.00002-09. Epub 2009 Apr 10.
2
Subchronic treatment with antiepileptic drugs modifies pentylenetetrazol-induced seizures in mice: Its correlation with benzodiazepine receptor binding.抗癫痫药物的亚慢性治疗可改变戊四氮诱导的小鼠癫痫发作：与苯二氮䓬受体结合的相关性。
Neuropsychiatr Dis Treat. 2008 Jun;4(3):619-25. doi: 10.2147/ndt.s2118.
3
Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract.大花假虎刺（夹竹桃科）根皮提取物的抗惊厥活性。
J Ethnopharmacol. 2008 Nov 20;120(2):255-8. doi: 10.1016/j.jep.2008.08.029. Epub 2008 Sep 4.
4
Antiepileptic ceramides from the Red Sea sponge Negombata corticata.来自红海海绵Negombata corticata的抗癫痫神经酰胺。
J Nat Prod. 2008 Apr;71(4):513-5. doi: 10.1021/np0703287. Epub 2008 Mar 21.
5
Sponge-associated microorganisms: evolution, ecology, and biotechnological potential.海绵相关微生物：进化、生态及生物技术潜力
Microbiol Mol Biol Rev. 2007 Jun;71(2):295-347. doi: 10.1128/MMBR.00040-06.
6
Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy.缝隙连接阻滞剂在难治性局灶性皮质癫痫大鼠模型中的抗癫痫作用
Epilepsia. 2006 Jul;47(7):1169-75. doi: 10.1111/j.1528-1167.2006.00540.x.
7
7,11-epi-thyrsiferol: completion of its synthesis, evaluation of its antimitotic properties, and the further development of an SAR model.7,11-表-甲状腺甾醇：其合成的完成、抗有丝分裂特性的评估以及构效关系模型的进一步发展。
J Org Chem. 2006 Aug 4;71(16):5936-41. doi: 10.1021/jo060519z.
8
Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics.弱镇痛药和非镇痛药对苯醌诱发小鼠扭体反应频率的拮抗作用。
J Pharmacol Exp Ther. 1959 Mar;125(3):237-40.
9
A method for evaluating both non-narcotic and narcotic analgesics.一种评估非麻醉性和麻醉性镇痛药的方法。
Proc Soc Exp Biol Med. 1957 Aug-Sep;95(4):729-31. doi: 10.3181/00379727-95-23345.
10
Antinociceptive effects of Teucrium polium L total extract and essential oil in mouse writhing test.百里香叶总提取物和精油在小鼠扭体试验中的抗伤害感受作用。
Pharmacol Res. 2003 Jul;48(1):31-5.

地中海海绵 Spongia officinalis 的防御分泌物的粗提物及其馏分的抗惊厥和镇痛活性。

Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis.

机构信息

Laboratoire de biotechnologie et Valorisation de Bio Géo Ressources (LBVBGR) Institut Supérieur de Biotechnologie, ISBST BioTechPole Sidi Thabet Université Manouba, Ariana, 2020, Tunisie.

出版信息

Cancer Cell Int. 2012 Apr 11;12(1):15. doi: 10.1186/1475-2867-12-15.

DOI:10.1186/1475-2867-12-15
PMID:22494441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3407508/
Abstract

This study progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with anticonvulsant and analgesic activities. We investigated the efficacy of crude extract and its semi-purified fractions (F1-F3) of the defensive secretion from Spongia officinalis for their in vivo anticonvulsant activity using the pentylenetetrazole (PTZ) seizure model and analgesic activity using the writhing test in mice. Among the series the crude extract exhibited interesting analgesic activity in a dose dependent manner. Similarly the fraction F2 showed a partial protection of mice from PTZ-induced seizure and interesting analgesic activity in a dose dependent manner. The purification and the determination of chemical structure(s) of compound(s) of this active fraction are under investigation.

摘要

本研究旨在从地中海海绵 Spongia officinalis 中鉴定具有抗惊厥和镇痛活性的成分。我们研究了来自 Spongia officinalis 的防御分泌物的粗提物及其半纯化部分（F1-F3）在戊四唑（PTZ）惊厥模型中的体内抗惊厥活性和在小鼠扭体试验中的镇痛活性。在该系列中，粗提物表现出剂量依赖性的有趣镇痛活性。同样，F2 部分也显示出对 PTZ 诱导的惊厥有部分保护作用，并具有剂量依赖性的有趣镇痛活性。目前正在对该活性部分化合物的分离和化学结构的确定进行研究。