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海绵属物种在海洋铅化合物发现中的作用。

The Role of Spongia sp. in the Discovery of Marine Lead Compounds.

作者信息

Máximo Patrícia, Ferreira Luísa M, Branco Paula, Lima Pedro, Lourenço Ana

机构信息

LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal.

Sea4Us-Biotecnologia de Recursos Marinhos, Ltd., 8650-378 Sagres, Portugal.

出版信息

Mar Drugs. 2016 Jul 23;14(8):139. doi: 10.3390/md14080139.

DOI:10.3390/md14080139
PMID:27455286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4999901/
Abstract

A comprehensive review on the chemistry of Spongia sp. is here presented, together with the biological activity of the isolated compounds. The compounds are grouped in sesquiterpene quinones, diterpenes, C21 and other linear furanoterpenes, sesterterpenes, sterols (including secosterols), macrolides and miscellaneous compounds. Among other reports we include studies on the intraspecific diversity of a Mediterranean species, compounds isolated from associated sponge and nudibranch and compounds isolated from S. zimocca and the red seaweed Laurentia microcladia. Under biological activity a table of the reported biological activities of the various compounds and the biological screening of extracts are described. The present review covers the literature from 1971 to 2015.

摘要

本文对海绵属物种的化学性质以及分离出的化合物的生物活性进行了全面综述。这些化合物分为倍半萜醌、二萜、C21及其他线性呋喃萜、链状四萜、甾醇（包括开环甾醇）、大环内酯类化合物和其他化合物。在其他报告中，我们纳入了关于一种地中海物种种内多样性的研究、从相关海绵和裸鳃亚目动物中分离出的化合物，以及从齐莫卡海绵和红海藻小枝劳伦氏藻中分离出的化合物。在生物活性方面，描述了各种化合物已报道的生物活性表以及提取物的生物筛选情况。本综述涵盖了1971年至2015年的文献。

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Biomolecules. 2021 May 12;11(5):723. doi: 10.3390/biom11050723.
9
Cytotoxic Furanoditerpenes from the Sponge Collected in the Mexican Caribbean.从墨西哥加勒比海域采集的海绵中分离得到的细胞毒性呋喃二萜。
Mar Drugs. 2019 Jul 16;17(7):416. doi: 10.3390/md17070416.
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Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro in Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis.探索 Solomonamide A 生物活性前体的抗血管生成潜力：体外和体内证据表明 Solo F-OH 在血管生成过程中的抑制活性。
Mar Drugs. 2019 Apr 15;17(4):228. doi: 10.3390/md17040228.
Bioorg Med Chem Lett. 2013 Jan 1;23(1):117-8. doi: 10.1016/j.bmcl.2012.11.001. Epub 2012 Nov 10.
4
Evaluation of antiproliferative and anti-inflammatory activities of methanol extract and its fractions from the Mediterranean sponge.评价地中海海绵甲醇提取物及其馏分的抗增殖和抗炎活性。
Cancer Cell Int. 2012 May 15;12(1):18. doi: 10.1186/1475-2867-12-18.
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Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis.地中海海绵 Spongia officinalis 的防御分泌物的粗提物及其馏分的抗惊厥和镇痛活性。
Cancer Cell Int. 2012 Apr 11;12(1):15. doi: 10.1186/1475-2867-12-15.
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High-throughput screening of Australian marine organism extracts for bioactive molecules affecting the cellular storage of neutral lipids.高通量筛选澳大利亚海洋生物提取物中影响中性脂质细胞储存的生物活性分子。
PLoS One. 2011;6(8):e22868. doi: 10.1371/journal.pone.0022868. Epub 2011 Aug 8.
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Terpenoid metabolites from Spongia spp. and their effects on nucleic acid biosynthesis in sea urchin eggs.来自海绵属物种的萜类代谢产物及其对海胆卵核酸生物合成的影响。
Nat Prod Commun. 2011 Jun;6(6):773-6.
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Patterns of chemical diversity in the Mediterranean sponge Spongia lamella.地中海海绵 Spongia lamella 中的化学多样性模式。
PLoS One. 2011;6(6):e20844. doi: 10.1371/journal.pone.0020844. Epub 2011 Jun 17.
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Bioactive terpenes from Spongia officinalis.从药用海绵中提取的生物活性萜类化合物。
J Nat Prod. 2011 May 27;74(5):1241-7. doi: 10.1021/np200226u. Epub 2011 May 6.
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3β, 5α-Dihydroxy-6β-Methoxycholest-7-enes from the Marine Sponge Spongia agaricina.来自海洋海绵琼脂海绵的3β, 5α-二羟基-6β-甲氧基胆甾-7-烯
J Nat Prod. 1988 Sep;51(5):999-1002. doi: 10.1021/np50059a036.