Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Atherosclerosis. 2012 Aug;223(2):269-77. doi: 10.1016/j.atherosclerosis.2012.03.017. Epub 2012 Mar 23.
Evidence is accumulating to support cell-based therapies as a new approach for chronic diseases. Perhaps the area of greatest impact, in terms of patient numbers, is cardiovascular disorders. This review considers cell transplantation as a potential treatment for peripheral vascular disease, including ischemic stroke and erectile dysfunction. Bone marrow derived cells are required for endogenous repair in adult individuals affected by angiopathies. Clinical trials using progenitor cells generated from monocytic or non-monocytic cells indicate that both are effective, suggesting that angiogenesis is the result of cross talk between different cells and pathways. Currently, there are 14 registered clinical trials (ClinicalTrials.gov) examining different approaches to stem cell therapy to cure peripheral artery disease, of which 6 have completed enrollment. Here, we will review published clinical studies that used cell transplantation for peripheral vascular ischemic disorders.
证据不断积累，支持细胞疗法作为治疗慢性疾病的新方法。就患者数量而言，影响最大的领域可能是心血管疾病。本综述考虑了细胞移植作为治疗外周血管疾病（包括缺血性中风和勃起功能障碍）的一种潜在方法。骨髓来源的细胞对于受血管疾病影响的成年个体的内源性修复是必需的。使用源自单核细胞或非单核细胞的祖细胞进行的临床试验表明，两者都有效，这表明血管生成是不同细胞和途径之间相互作用的结果。目前，有 14 项注册临床试验（ClinicalTrials.gov）正在研究治疗外周动脉疾病的干细胞疗法的不同方法，其中 6 项已完成入组。在这里，我们将回顾已发表的使用细胞移植治疗外周血管缺血性疾病的临床研究。
