血管疾病等待着由干细胞构建的血管的转化应用。
Vascular diseases await translation of blood vessels engineered from stem cells.
作者信息
Samuel Rekha, Duda Dan G, Fukumura Dai, Jain Rakesh K
机构信息
Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Centre for Stem Cell Research, Christian Medical College, Bagayam, Vellore 632002, Tamil Nadu, India.
Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
出版信息
Sci Transl Med. 2015 Oct 14;7(309):309rv6. doi: 10.1126/scitranslmed.aaa1805.
Abstract
The discovery of human induced pluripotent stem cells (hiPSCs) might pave the way toward a long-sought solution for obtaining sufficient numbers of autologous cells for tissue engineering. Several methods exist for generating endothelial cells or perivascular cells from hiPSCs in vitro for use in the building of vascular tissue. We discuss current developments in the generation of vascular progenitor cells from hiPSCs and the assessment of their functional capacity in vivo, opportunities and challenges for the clinical translation of engineered vascular tissue, and modeling of vascular diseases using hiPSC-derived vascular progenitor cells.
摘要
人类诱导多能干细胞（hiPSC）的发现可能为获取足够数量的自体细胞用于组织工程这一长期寻求的解决方案铺平道路。目前存在多种在体外从hiPSC生成内皮细胞或血管周细胞以用于构建血管组织的方法。我们讨论了从hiPSC生成血管祖细胞的当前进展及其体内功能能力的评估、工程化血管组织临床转化的机遇与挑战，以及使用hiPSC衍生的血管祖细胞对血管疾病进行建模。
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