State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
Colloids Surf B Biointerfaces. 2012 Jun 15;95:274-8. doi: 10.1016/j.colsurfb.2012.03.012. Epub 2012 Mar 28.
A range of mesoporous silica nanoparticles (MSNs) with controlled microstructural characteristics were successfully prepared via the binary surfactant templated synthesis approach with varied concentration of triblock copolymer Pluronic F127. The relationship between the MSNs structural evolution and the surfactant concentration was extensively discussed. Ibuprofen (IBU) was loaded as drug model to uncover the in vitro drug releasing kinetics. It was found that the quantity of the drug loaded mainly depended on the specific surface area, while the drug releasing rate was dominantly determined by the length and curvature of the mesopores. This study has uncovered the core influential factors of MSNs system on its drug releasing properties, and thus demonstrated a facile approach to prepare MSNs with manipulated structural characteristics for drug delivery applications.
通过二元表面活性剂模板合成方法，成功制备了一系列具有可控微观结构特征的介孔硅纳米粒子（MSNs），其中表面活性剂聚氧乙烯-聚氧丙烯-聚氧乙烯三嵌段共聚物 Pluronic F127 的浓度不同。详细讨论了 MSNs 结构演变与表面活性剂浓度之间的关系。以布洛芬（IBU）为药物模型，揭示了体外药物释放动力学。结果表明，药物的载药量主要取决于比表面积，而药物释放速率主要取决于介孔的长度和曲率。该研究揭示了 MSNs 体系对其药物释放性能的核心影响因素，从而为制备具有可控结构特征的用于药物输送的 MSNs 提供了一种简便的方法。
