Working Group Cardiac MR, Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany.
Int J Cardiol. 2013 Aug 10;167(3):905-9. doi: 10.1016/j.ijcard.2012.03.104. Epub 2012 Apr 10.
Excessive myocardial triglyceride (MTG) content in obesity and type 2 diabetes is associated with impaired cardiac function. Previous studies suggest that MTG could be mobilized through lifestyle interventions. We assessed influences of moderate dietary weight loss in non diabetic obese and overweight women on MTG content and cardiac function.
We selected a subgroup of 38 women from the B-SMART study population. The B-SMART study compared weight loss and associated metabolic and cardiovascular markers with reduced-carbohydrate and reduced-fat hypocaloric diets. Selected subjects had completed a cardiac magnetic resonance (MR) scan including imaging and proton spectroscopy to assess cardiac structure and function as well as MTG content.
An average weight reduction of 5.4 ± 4.3 kg at six months was associated with a relative decrease of MTG of 25% (from 0.72 ± 0.29% at baseline to 0.54 ± 0.23% at follow-up, p<0.001). The response was similar with carbohydrate and fat restriction. Diastolic function expressed as ratio of peak filling rate in E- and A-Phase (PFRE/PFRA) was unchanged. Reductions of left atrial size (from 21.9 ± 4.0 cm(2) to 20.0 ± 3.7 cm(2), p=0.002), the normalized ratio of PFRE and early diastolic lengthening velocity PLV (from 8.2 ± 2.6 to 7.5 ± 2.5, p<0.001) and fat free mass (from 55.1 ± 6.9 kg to 52.7 ± 6.5 kg, p=0.007) reflected altered cardiac volume loading after diet, but did not correlate to MTG content.
Moderate dietary weight loss significantly reduced MTG content in women with uncomplicated overweight or obesity. Macronutrient composition of the diet did not significantly affect the extent of MTG reduction.
肥胖和 2 型糖尿病患者心肌甘油三酯（MTG）含量过高与心脏功能受损有关。先前的研究表明，通过生活方式干预可以动员 MTG。我们评估了非糖尿病肥胖和超重女性适度饮食减肥对 MTG 含量和心脏功能的影响。
我们从 B-SMART 研究人群中选择了 38 名女性亚组。B-SMART 研究比较了低碳水化合物和低脂肪热量限制饮食在减肥和相关代谢及心血管标志物方面的差异。入选的受试者完成了心脏磁共振（MR）扫描，包括成像和质子波谱，以评估心脏结构和功能以及 MTG 含量。
6 个月时平均体重减轻 5.4 ± 4.3 kg，与 MTG 相对减少 25%（从基线时的 0.72 ± 0.29%降至随访时的 0.54 ± 0.23%，p<0.001）相关。碳水化合物和脂肪限制的反应相似。舒张功能以 E 期和 A 期峰值充盈率之比（PFRE/PFRA）表示，无变化。左心房大小减小（从 21.9 ± 4.0 cm2 降至 20.0 ± 3.7 cm2，p=0.002），PFRE 和早期舒张伸长速度 PLV 的归一化比值（从 8.2 ± 2.6 降至 7.5 ± 2.5，p<0.001）和去脂体重（从 55.1 ± 6.9 kg 降至 52.7 ± 6.5 kg，p=0.007）反映了饮食后心脏容量负荷的变化，但与 MTG 含量无关。
适度饮食减肥可显著降低非糖尿病肥胖和超重女性的 MTG 含量。饮食中的宏量营养素组成对 MTG 减少的程度没有显著影响。
