He B
Haerbin Medical College.
Zhonghua Zhong Liu Za Zhi. 1990 May;12(3):190-2.
In a co-culture system of human lung adenocarcinoma cells (LTEP-a2) with tissue fragments of human heart and liver, it was found that the target organs were destroyed with cancer cells invading. The destruction shown as cell swelling, atrophy, fatty degeneration and disappearance of the cardiac muscle streak, myocomma and local cell membrane, always occurred at sites immediately in contact with the invading cancer cells. However, cell changes could develop not in direct contact with tumor cells. The farther invasion by the tumor cells, the more serious destruction was seen. It was also observed that the tumor cytoplasmic processes could surround debris derived from the target tissue and the debris could be found inside cancer cells. The rapidly invading cells contained more phagosomes than the slowly invading ones.
在人肺腺癌细胞（LTEP-a2）与人心和肝组织碎片的共培养体系中，发现随着癌细胞的侵袭，靶器官遭到破坏。破坏表现为细胞肿胀、萎缩、脂肪变性以及心肌条纹、肌节和局部细胞膜的消失，这些破坏总是发生在与侵袭癌细胞直接接触的部位。然而，细胞变化也可能在未与肿瘤细胞直接接触的情况下发生。肿瘤细胞侵袭得越远，破坏就越严重。还观察到肿瘤细胞质突起可以包围来自靶组织的碎片，并且在癌细胞内可以发现这些碎片。快速侵袭的细胞比缓慢侵袭的细胞含有更多的吞噬体。
