He B
Harbin Medical College.
Zhonghua Zhong Liu Za Zhi. 1991 Jan;13(1):16-9.
The invasiveness of human lung adenocarcinoma cell line LTEP-a2 was investigated in co-culture system of tumor cells and fragments of the heart and liver from the newborn, rabbit and rat. It was found that the tumor cells had different invasive behaviors, for example cell diastrophism, proliferation or invasion speed and adenic formation when invading various species or various organs in the same species. When invading the fragments of newborn heart and liver, strong cell diastrophism potential, cell twist or formation of multiprocess pseudopodia and mitosis could be observed. The result was contrary to the above when the fragments of rat heart and liver were used as the target. When the fragments of rabbit liver were invaded, marked adenization was formed by cancer cells with the invading speed increased. However, the adenic structure was absent as the heart fragments of rabbit were invaded. The results indicate that target organs could change biological behavior of the invading tumor cells to different degrees even their differentiation. It may be related to structure and biochemical property of the target organs.
在肿瘤细胞与新生兔、大鼠心脏及肝脏组织碎片的共培养体系中，研究了人肺腺癌细胞系LTEP-a2的侵袭能力。结果发现，肿瘤细胞在侵袭不同物种或同一物种的不同器官时，具有不同的侵袭行为，如细胞变形、增殖或侵袭速度以及腺管形成等。当侵袭新生心脏和肝脏组织碎片时，可观察到较强的细胞变形潜能、细胞扭曲或多伪足形成以及有丝分裂。而以大鼠心脏和肝脏组织碎片为靶点时，结果则相反。当侵袭兔肝脏组织碎片时，癌细胞形成明显的腺管样结构，且侵袭速度加快。然而，当侵袭兔心脏组织碎片时，则无腺管样结构形成。结果表明，靶器官即使在分化程度相同的情况下，也能在不同程度上改变侵袭肿瘤细胞的生物学行为。这可能与靶器官的结构和生化特性有关。
