Jun Hyung Jin, Chang Jiwon, Im Gi Jung, Kwon Soon-Young, Jung Hakhyun, Choi June
Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Ansan, Korea.
Acta Otolaryngol. 2012 Jun;132(6):590-6. doi: 10.3109/00016489.2011.652306. Epub 2012 Apr 12.
The combination of systemic steroids with intratympanic dexamethasone injection (ITDI) did not result in significantly different outcomes from steroid treatment only and did not have any additional beneficial effects.
To evaluate hearing recovery in idiopathic sudden sensorineural hearing loss (ISSNHL) according to frequency and to compare treatment responses between patients treated with systemic steroids and systemic steroids with ITDI.
Ninety-nine patients with ISSNHL were selected to participate in the study by a retrospective medical chart review. Patients were divided into two groups, systemic steroid treatment only and systemic steroid with adjunctive ITDI. Hearing recovery was evaluated by pure tone audiometry (PTA). All patients underwent PTA examination before treatment and after 3 months. Thresholds were analyzed by frequency along with other factors.
Low frequency hearing loss responded better than high frequency loss to PTA. When we analyzed pure tone audiogram patterns, all patterns except for the descending type showed better improvement in patients with lower frequency hearing loss than in patients with higher frequency hearing loss.
全身用类固醇激素联合鼓室内注射地塞米松（ITDI）与单纯使用类固醇激素治疗相比，疗效无显著差异，且无额外益处。
根据频率评估特发性突发性感音神经性听力损失（ISSNHL）的听力恢复情况，并比较全身用类固醇激素治疗患者与全身用类固醇激素联合ITDI治疗患者的治疗反应。
通过回顾性病历审查，选取99例ISSNHL患者参与研究。患者分为两组，一组仅接受全身用类固醇激素治疗，另一组接受全身用类固醇激素联合辅助ITDI治疗。通过纯音听力测试（PTA）评估听力恢复情况。所有患者在治疗前和治疗3个月后均接受PTA检查。对阈值进行频率分析及其他因素分析。
PTA显示低频听力损失的反应优于高频听力损失。当分析纯音听力图模式时，除下降型外，所有模式在低频听力损失患者中的改善均优于高频听力损失患者。
