St Vincent's Hospital and ACEBAC, La Trobe University, Melbourne, Victoria, Australia.
Pain Med. 2012 Apr;13 Suppl 2:S72-8. doi: 10.1111/j.1526-4637.2011.01315.x.
Evidence-based medicine has been adopted as a means of achieving optimal medical care and to reduce variations in clinical practice. Randomised controlled trials are considered the highest level of scientific evidence. Older individuals are either excluded or underrepresented in these studies, and those who are included are often atypical of patients seen in clinical practice.
To examine the approach to clinical decision making in frail older persons when there is little or no scientific evidence to guide management.
A case study is presented of refractory post herpetic neuralgia in a frail older person. Management plans were developed combining the scientific evidence from the pain literature with the practice known as Comprehensive Geriatric Assessment. The rationale and evidence for clinical decision making is explored.
Standard therapies for post herpetic neuralgia had been ineffective or limited by side effects in this patient. By a process of trial and error a combination of treatments was found that improved pain and mood but adversely affected cognition. Adjustment in treatments over time resulted in improved pain, mood, and cognition.
The art of medicine is not the antithesis of the scientific approach. The art of medicine involves balancing the scientific evidence with the circumstances and the preferences of the patient. Combining the practices of Pain Medicine and Comprehensive Geriatric Assessment may result in a better outcome. When treating older people, clinicians not only need to take into consideration the severity of pain, but also the impact of pain and its treatment on cognition, mood and functional status.
循证医学已被采纳为实现最佳医疗保健和减少临床实践差异的手段。随机对照试验被认为是最高水平的科学证据。在这些研究中,老年人要么被排除在外,要么代表性不足,而被纳入的老年人往往与临床实践中看到的患者不同。
当几乎没有或没有科学证据来指导管理时,研究虚弱老年人在临床决策中的方法。
提出了一个虚弱老年人难治性疱疹后神经痛的病例研究。结合疼痛文献中的科学证据和综合老年评估的实践,制定了管理计划。探讨了临床决策的基本原理和证据。
在该患者中,疱疹后神经痛的标准治疗要么无效,要么因副作用而受限。通过反复试验,找到了一种治疗方法的组合,改善了疼痛和情绪,但对认知产生了不利影响。随着时间的推移,治疗方法的调整改善了疼痛、情绪和认知。
医学艺术不是科学方法的对立面。医学艺术涉及平衡科学证据与患者的情况和偏好。结合疼痛医学和综合老年评估的实践可能会带来更好的结果。治疗老年人时,临床医生不仅需要考虑疼痛的严重程度,还需要考虑疼痛及其治疗对认知、情绪和功能状态的影响。