兔肿瘤坏死因子基因座的结构分析，该基因座包含编码肿瘤坏死因子-β（淋巴毒素）和肿瘤坏死因子-α（肿瘤坏死因子）的基因。
Structural analysis of the rabbit TNF locus, containing the genes encoding TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis factor).
作者信息
Shakhov A N, Kuprash D V, Azizov M M, Jongeneel C V, Nedospasov S A
机构信息
Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow.
出版信息
Gene. 1990 Nov 15;95(2):215-21. doi: 10.1016/0378-1119(90)90364-w.
The genes coding for 20-kDa lymphotoxin (TNF-beta) and tumor necrosis factor (TNF-alpha) have been cloned from a rabbit genomic library. The two genes are tandemly arranged and separated by only 1 kb of DNA, as previously observed in human and mouse genomes. We have sequenced the entire rabbit lymphotoxin-encoding gene and inferred the primary structure of rabbit TNF-beta, whose cDNA is not yet cloned. We also analysed the upstream sequences of the rabbit TNF-beta and TNF-alpha genes and identified a number of potential binding sites for known nuclear transcription factors, and in particular several putative kappa B-type sequences.
编码20-kDa淋巴毒素（TNF-β）和肿瘤坏死因子（TNF-α）的基因已从兔基因组文库中克隆出来。这两个基因串联排列，仅被1 kb的DNA隔开，正如先前在人类和小鼠基因组中观察到的那样。我们已经对整个兔淋巴毒素编码基因进行了测序，并推断出兔TNF-β的一级结构，其cDNA尚未克隆。我们还分析了兔TNF-β和TNF-α基因的上游序列，并确定了许多已知核转录因子的潜在结合位点，特别是几个假定的κB型序列。
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