轴突变性：Wlds 的作用。
Axon degeneration: where the Wlds things are.
机构信息
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Curr Biol. 2012 Apr 10;22(7):R221-3. doi: 10.1016/j.cub.2012.02.056.
Abstract
Expression of the Wld(s) protein significantly delays axon degeneration in injuries and diseases, but the mechanism for this protection is unknown. Two recent reports present evidence that axonal mitochondria are required for Wld(S)-mediated axon protection.
摘要
Wld(s) 蛋白的表达显著延缓了损伤和疾病中的轴突变性，但这种保护的机制尚不清楚。最近的两项研究报告提供了证据，表明轴突线粒体是 Wld(S)介导的轴突保护所必需的。
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本文引用的文献
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WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.WldS 通过增加线粒体流量和增强线粒体钙缓冲来防止轴突退化。
Curr Biol. 2012 Apr 10;22(7):596-600. doi: 10.1016/j.cub.2012.02.043. Epub 2012 Mar 15.
2
A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity.一种新型果蝇神经损伤模型揭示了 Nmnat 在维持轴突完整性方面的重要作用。
Curr Biol. 2012 Apr 10;22(7):590-5. doi: 10.1016/j.cub.2012.01.065. Epub 2012 Mar 15.
3
Axon degeneration: molecular mechanisms of a self-destruction pathway.轴突变性：自我毁灭途径的分子机制。
J Cell Biol. 2012 Jan 9;196(1):7-18. doi: 10.1083/jcb.201108111.
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