白细胞介素 1β 多态性及其单倍型与阿尔茨海默病的关联。
Association of interleukin 1β polymorphisms and haplotypes with Alzheimer's disease.
机构信息
Universidade do Sagrado Coração, USC, Bauru, São Paulo, Brazil.
出版信息
J Neuroimmunol. 2012 Jun 15;247(1-2):59-62. doi: 10.1016/j.jneuroim.2012.03.012. Epub 2012 Apr 10.
Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1β) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population.
本研究旨在比较巴西圣保罗的老年对照组，探讨白细胞介素 1β（IL-1β）和白细胞介素 1 受体拮抗剂（IL-1RN）多态性与 AD 疾病的相关性。我们对 199 例阿尔茨海默病（AD）患者、165 例老年对照组和 122 例青年对照组样本进行了 VNTR（IL-1RN）和 -511C>T 和 -31T>C（IL-1β）多态性的基因分型。我们的研究结果表明，与 EC 相比，-511C/-31T/2 重复 VNTR 单倍型对 AD 具有保护作用（p=0.005），而 -511C/-31C/1 重复 VNTR 单倍型与 AD 的风险因素相关（p=0.021）。综上所述，我们可以认为在巴西人群中，IL-1 基因簇在 AD 发病机制中具有重要作用。
Zotero 插件