白细胞介素 (IL) 1β (g.-511C>T 和 g.+3954C>T) 和 IL-1RN 基因多态性与多囊卵巢综合征的关系。
Genotype and haplotype determination of interleukin (IL) 1 beta (g. -511C>T and g. +3954C>T) and IL-1RN in polycystic ovary syndrome.
机构信息
Department of Obstetrics and Gynecology, Peking University Third Hospital, HaiDian District, Beijing, People's Republic of China.
出版信息
Fertil Steril. 2010 Jun;94(1):384-6. doi: 10.1016/j.fertnstert.2009.09.042. Epub 2009 Nov 11.
The distribution of genotype frequencies, allele frequencies, and haplotype frequencies of variable number of tandem repeats (VNTR) in interleukin (IL) 1RN and IL-1beta (-511C > T, exon-5C.>T) polymorphism demonstrated a positive association with the occurrence of polycystic ovary syndrome (PCOS). The carriage of allele V of IL-1RN and allele E1 of exon-5 on the IL-1beta gene may increase the risk of PCOS.
可变数目串联重复（VNTR）的白细胞介素（IL）1RN 和 IL-1β（-511C>T，exon-5C.>T）多态性的基因型频率、等位基因频率和单倍型频率的分布与多囊卵巢综合征（PCOS）的发生呈正相关。IL-1RN 的等位基因 V 和 IL-1β 基因exon-5 的等位基因 E1 的携带可能会增加 PCOS 的风险。
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