睾酮可促进老年和年轻小鼠骨骼肌的再生。
Testosterone improves the regeneration of old and young mouse skeletal muscle.
机构信息
Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston, MA 02118, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):17-26. doi: 10.1093/gerona/gls083. Epub 2012 Apr 12.
Abstract
Aging is associated with loss of muscle mass and strength, reduced satellite cell number, and lower regenerative potential. Testosterone increases muscle mass, strength, and satellite cell number in humans; however, the effects of testosterone on the regenerative potential of skeletal muscle are unclear. Here, we investigated the effect of testosterone on the skeletal muscle regeneration of young (2-month-old) and aged (24-month-old) male mice. We show that testosterone increases the number of proliferating satellite cells in regenerating "tibialis anterior" muscle of young and aged castrated mice 2 and 4 days postinjury. Testosterone supplementation increases the number and the cross-sectional area of regenerating fibers in both classes of age 4 days postinjury. Testosterone increases satellite cell activation and proliferation and the regeneration of both young and aged mouse muscle. These data suggest prospective application of androgens to improve the regenerating potential of the aged human skeletal muscle.
摘要
衰老是与肌肉质量和力量的丧失、卫星细胞数量减少以及再生潜能降低有关。睾丸激素可增加人体的肌肉质量、力量和卫星细胞数量；然而，睾丸激素对骨骼肌再生潜能的影响尚不清楚。在这里，我们研究了睾丸激素对年轻（2 个月大）和年老（24 个月大）雄性小鼠骨骼肌再生的影响。我们发现，睾丸激素增加了年轻和年老去势雄性小鼠“胫骨前肌”再生中增殖卫星细胞的数量，在损伤后 2 天和 4 天。睾丸激素补充增加了损伤后 4 天两类年龄的再生纤维的数量和横截面积。睾丸激素增加了年轻和年老小鼠肌肉中卫星细胞的激活和增殖以及再生。这些数据表明雄激素具有改善人类骨骼肌再生潜能的应用前景。
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