Boyle P, Macfarlane G J, Maisonneuve P, Zheng T, Scully C, Tedesco B
Unit of Analytical Epidemiology, International Agency for Research on Cancer, Lyon, France.
J R Soc Med. 1990 Nov;83(11):724-30. doi: 10.1177/014107689008301116.
The oral cavity and pharynx combined is the sixth commonest site of cancer in both sexes. In many countries the mortality rate is increasing among younger men born since approximately 1910-1920. A causal role in the aetiology of mouth cancer has been established for tobacco use, both smoking and chewing, separately and in conjunction with betel-quid chewing; with alcohol consumption and, less certainly, with other factors such as poor oral hygiene, nutritional factors and certain occupational exposures. In Western countries, there is convincing evidence that a large attributable risk can be ascribed to the joint habits of cigarette smoking and alcohol consumption. In Asian societies, a high attributable risk can be ascribed to cigarette smoking and betel chewing. Mouth cancer is at the same time an important form of cancer, and one for which practical prospects for prevention already exist. Against this background of a continually increasing trend among younger persons, it seems essential to engage upon programmes of prevention, including increasing awareness for early detection, against mouth cancer at the present time.
口腔和咽相结合是男女中第六大最常见的癌症部位。在许多国家,自大约1910年至1920年出生的较年轻男性中,死亡率正在上升。吸烟和咀嚼烟草,无论是单独使用还是与嚼槟榔一起使用,以及饮酒,以及不太确定的其他因素,如口腔卫生差、营养因素和某些职业暴露,在口腔癌病因学中都已确定具有因果作用。在西方国家,有令人信服的证据表明,很大一部分可归因风险可归因于吸烟和饮酒的共同习惯。在亚洲社会,很大一部分可归因风险可归因于吸烟和嚼槟榔。口腔癌同时是一种重要的癌症形式,而且目前已经存在实际的预防前景。在年轻人中这种趋势持续上升的背景下,目前开展预防口腔癌的项目,包括提高早期检测意识,似乎至关重要。