Institute of Botany, Academy of Sciences of the Czech Republic, Zamek 1, CZ-252 43 Průhonice, Czech Republic.
J Ethnopharmacol. 2012 Jun 14;141(3):761-74. doi: 10.1016/j.jep.2012.03.048. Epub 2012 Apr 5.
Rheum australe D. Don (Polygonaceae) has been commonly used in traditional medicine for a wide range of ailments related to the circulatory, digestive, endocrine, respiratory and skeletal systems as well as to infectious diseases.
To provide the up-to-date information that is available on the botany, traditional uses, phytochemistry, pharmacology and toxicology of Rheum australe. Additionally, to highlight the possible uses of this species to treat different diseases and to provide a basis for future research.
The present review covers the literature available from 1980 to 2011. The information was collected from scientific journals, books, theses and reports via a library and electronic search (Google Scholar, Web of Science and ScienceDirect).
Ethnomedical uses of Rheum australe have been recorded from China, India, Nepal and Pakistan for 57 different types of ailments. The phytochemical studies have shown the presence of many secondary metabolites belonging to anthraquinones, stilbenes, anthrones, oxantrone ethers and esters, chromones, flavonoids, carbohydrate, lignans, phenols and sterols. Crude extracts and isolated compounds from Rheum australe show a wide spectrum of pharmacological activities, such as antidiabetic, anti-inflammatory, antifungal, antimicrobial, antioxidant, anticancer, hepatoprotective and immune-enhancing activities, as well as a usefulness for improving renal function.
Rheum australe has been widely used source of medicine for years without any adverse effects. Many studies have provided evidence for various traditional uses. However, there is a need for additional studies of the isolated compounds to validate the traditional uses in human models. The present review on the botany, traditional uses, phytochemistry and toxicity has provided preliminary information for further studies and commercial exploitations of the plant.
藏边大黄（Polygonaceae）在传统医学中被广泛用于治疗与循环、消化、内分泌、呼吸和骨骼系统以及传染病相关的多种疾病。
提供有关藏边大黄的植物学、传统用途、植物化学、药理学和毒理学的最新信息。此外，强调该物种治疗不同疾病的可能用途，并为未来的研究提供基础。
本综述涵盖了 1980 年至 2011 年的文献。信息是通过图书馆和电子搜索（Google Scholar、Web of Science 和 ScienceDirect）从科学期刊、书籍、论文和报告中收集的。
藏边大黄在中国、印度、尼泊尔和巴基斯坦的 57 种不同疾病中被记录有民间用途。植物化学研究表明存在许多属于蒽醌、二苯乙烯、蒽酮、氧蒽酮醚和酯、色酮、类黄酮、碳水化合物、木脂素、酚类和甾醇的次生代谢物。藏边大黄的粗提取物和分离化合物表现出广泛的药理活性，如抗糖尿病、抗炎、抗真菌、抗菌、抗氧化、抗癌、保肝和增强免疫活性，以及改善肾功能的作用。
藏边大黄多年来一直被广泛用作药物，没有任何不良反应。许多研究为各种传统用途提供了证据。然而，需要对分离化合物进行更多的研究，以验证在人体模型中的传统用途。本综述对植物的植物学、传统用途、植物化学和毒性提供了初步信息，为进一步研究和商业开发该植物提供了依据。
