玉米低聚肽对大鼠酒精性肝损伤的保护作用。
Corn oligopeptides protect against early alcoholic liver injury in rats.
机构信息
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Xueyuan Road 38, Haidian District, Beijing 100191, PR China.
出版信息
Food Chem Toxicol. 2012 Jun;50(6):2149-54. doi: 10.1016/j.fct.2012.03.083. Epub 2012 Apr 13.
BACKGROUND
The present study aimed to investigate the effects of corn oligopeptides (COPs) on early alcoholic liver injury in rats. A total of 70 Wistar rats were randomly assigned to 7 groups, including a normal control group, 3 alcohol control groups (2.0, 4.0 and 6.0 g/kg/BW ethanol), and 3 COP intervention groups (2.0, 4.0 and 6.0 g/kg/BW ethanol, with 900 mg/kg/BW COPs). The study duration lasted for 4 weeks. Serum markers were assayed, and a histopathological examination was conducted.
RESULTS
We found that the COP treatment prevented the elevation of serum aminotransferase and alleviated the hepatic histological damage that was induced by alcohol. In addition, the COPs counteracted the changes in the SOD activity and the MDA content in serum. Furthermore, the COPs ameliorated the abnormal lipid metabolism.
CONCLUSION
These findings suggest that COPs have a significant protective effect on early alcoholic liver injury in rats.
背景
本研究旨在探讨玉米低聚肽（COPs）对大鼠酒精性肝损伤早期的影响。将 70 只 Wistar 大鼠随机分为 7 组，包括正常对照组、3 个酒精对照组（2.0、4.0 和 6.0 g/kg/BW 乙醇）和 3 个 COP 干预组（2.0、4.0 和 6.0 g/kg/BW 乙醇，用 900 mg/kg/BW COPs）。研究持续 4 周。测定血清标志物，并进行组织病理学检查。
结果
我们发现 COP 处理可预防血清转氨酶升高，并减轻酒精引起的肝组织损伤。此外，COPs 对抗了血清中超氧化物歧化酶活性和丙二醛含量的变化。此外，COPs 改善了异常的脂质代谢。
结论
这些发现表明 COPs 对大鼠酒精性肝损伤早期具有显著的保护作用。
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