Muangchan Chayawee, Pope Janet E
Division of Rheumatology, Department of Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand.
J Rheumatol. 2012 Jun;39(6):1120-4. doi: 10.3899/jrheum.111423. Epub 2012 Apr 15.
The purpose of this study was to review the potential importance of interleukin 6 (IL-6) in systemic sclerosis (SSc).
PubMed and Scopus databases and American College of Rheumatology (from 2009-10) and European League Against Rheumatism abstracts (2009-11) were searched using keywords "scleroderma; SSc; cytokines; interleukins; interleukin 6" and publications were excluded if not pertaining to IL-6 in SSc. Data were extracted from selected articles to construct a cell interaction model of the effects of IL-6 in SSc.
A total of 416 reports were found (PubMed, n = 82; Scopus, n = 331; 3 abstracts); 372 were excluded (irrelevant) leaving 41 publications and 3 abstracts (39 from PubMed, 18 from Scopus; but 16 were repeated from PubMed search), where 40 suggested IL-6 was important in SSc and 4 did not. Effects of IL-6 in SSc were summarized schematically.
Of the 44 publications, 40 suggested that IL-6 may be important in SSc, allowing for a conceptual framework within SSc including effects on macrophages, fibroblasts, plasma cells, monocytes, and extracellular matrix.
本研究旨在探讨白细胞介素6（IL-6）在系统性硬化症（SSc）中的潜在重要性。
使用关键词“硬皮病；系统性硬化症；细胞因子；白细胞介素；白细胞介素6”检索PubMed和Scopus数据库以及美国风湿病学会（2009 - 10年）和欧洲抗风湿病联盟摘要（2009 - 11年），若出版物与系统性硬化症中的IL-6无关则予以排除。从选定文章中提取数据，构建IL-6在系统性硬化症中作用的细胞相互作用模型。
共检索到416篇报告（PubMed，n = 82；Scopus，n = 331；3篇摘要）；排除372篇（不相关），剩余41篇出版物和3篇摘要（39篇来自PubMed，18篇来自Scopus；但16篇与PubMed搜索重复），其中40篇表明IL-6在系统性硬化症中很重要，4篇则未提及。对IL-6在系统性硬化症中的作用进行了示意性总结。
在这44篇出版物中，40篇表明IL-6可能在系统性硬化症中具有重要意义，这为系统性硬化症构建了一个概念框架，包括其对巨噬细胞、成纤维细胞、浆细胞、单核细胞和细胞外基质的影响。
