超级马拉松（308公里）比赛对骨代谢和软骨损伤生物标志物的影响。
Effect of Ultra-marathon (308 km) Race on Bone Metabolism and Cartilage Damage Biomarkers.
作者信息
Shin Kyung-A, Kim Al-Chan, Kim Young-Joo, Lee Yoon-Hee, Shin Young-Oh, Kim Sang-Hoon, Park Young-Sik, Nam Hee Seung, Kim Taikon, Kim Hyoung Seop, Park Yongbum
机构信息
Department of Laboratory Medicine, Bun-dang Je-saeng Hospital, Seongnam 463-824, Korea.
出版信息
Ann Rehabil Med. 2012 Feb;36(1):80-7. doi: 10.5535/arm.2012.36.1.80. Epub 2012 Feb 29.
OBJECTIVE
To evaluate the potential effects of a 308-km ultra-marathon on bone and cartilage biomarkers.
METHOD
Venous blood samples were collected at pre-race, 100 km, 200 km, and 308 km checkpoints. The following markers of cartilage damage and bone metabolism were studied: osteocalcin (OC), osteoprotegerin (OPG), and calcium, phosphorous, and cartilage oligomeric matrix protein (COMP).
RESULTS
Blood samples were taken from 20 male runners at four different checkpoints. Serum COMP was increased by 194.1% (130.7% at 100 km and 160.4% at 200 km). Serum OPG was significantly increased by 158.57% at 100 km and 114.1% at 200 km compared to the pre-race measures. OC was transiently suppressed at 200 km. Serum calcium and phosphorous concentrations decreased compared to the pre-race measures.
CONCLUSION
This study showed that the 308-km ultra-marathon induced several changes, including transient uncoupling of bone metabolism, increased bone resorption, suppressed bone formation, and bone turnover and had a major impact on cartilage structure.
目的
评估一场308公里超级马拉松对骨骼和软骨生物标志物的潜在影响。
方法
在赛前、100公里、200公里和308公里检查点采集静脉血样。研究了以下软骨损伤和骨代谢标志物：骨钙素（OC）、骨保护素（OPG）以及钙、磷和软骨寡聚基质蛋白（COMP）。
结果
在四个不同检查点从20名男性跑步者身上采集了血样。血清COMP增加了194.1%（100公里处增加130.7%，200公里处增加160.4%）。与赛前测量值相比，血清OPG在100公里处显著增加了158.57%，在200公里处增加了114.1%。OC在200公里处短暂受到抑制。血清钙和磷浓度与赛前测量值相比有所下降。
结论
本研究表明，这场308公里超级马拉松引发了多种变化，包括骨代谢的短暂解偶联、骨吸收增加、骨形成受抑制以及骨转换，并且对软骨结构产生了重大影响。
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