[Expression of TGM3 protein and its significance in laryngeal carcinoma].

OBJECTIVE

To investigate the expression of TGM3 in laryngeal carcinoma and analyze the relation of TGM3 and clinical factors.

METHOD

We measured the expression of TGM3 protein in 50 laryngeal carcinoma fresh samples and 50 para-carcinoma tissues (to cutting margin > 0.5 cm) by Flow Cytometry (Epics-XL II), 20 normal laryngeal mucosa samples were also studied as controls.

RESULT

1. The quantitative and qualitative expression of TGM3 protein in laryngeal carcinoma tissues is obviously lower than those in para-carcinoma and normal laryngeal mucosa tissues respectively (P<0.05). There is no significant expression difference between the para-carcinoma and normal laryngeal mucosa tissues. 2) In laryngeal carcinoma, the expression of TGM3 protein isn't significantly related to patients' clinical classification, tumor size, patients' age and gender but related to lymphaden metastasis. differentiation and clinical stage.

CONCLUSION

The low expression of TGM3 may contribute to the carcinogenesis and development of laryngeal carcinoma. It is an important index of judging differentiation, infiltration, metastasis and staging of laryngeal carcinoma by measure the expression of TGM3 protein.