Ye Fei, Huang Guiqiu, Fu Minyi, Ma Yongzhong, Kang Hongjian
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Zhongshan, Sun Yat-sen University, Zhongshan 528403, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Feb;27(3):136-9.
To investigate the expression of SOX2 in laryngeal carcinoma and analyze the relation of SOX2 and clinical factors.
We measured the expression of SOX2 protein in 45 laryngeal carcinoma fresh samples and 45 paracarcinoma tissues (cutting margin > 0.5 cm) with flow cytometer (Epics-XL II), 20 normal laryngeal mucosa samples were also studied as controls.
The quantitative and qualitative expression of SOX2 protein in laryngeal carcinoma tissues was obviously higher than those in paracarcinoma and in normal laryngeal mucosa tissues respectively (P < 0 05). There was no significant difference between the expression of paracarcinoma and normal laryngeal mucosa tissues. In laryngeal carcinoma, the expression of SOX2 protein wasn't significantly related to patients' clinical classification, tumor size, smoking history, patients' age and sex but related to metastasis, pathological grade and clinical stage.
The high expression of SOX2 may contribute to the carcinogenesis and development of laryngeal carcinoma. It is an important index of judging metastasis and staging and prognosis of laryngeal carcinoma to measure the expression of SOX2 protein.
探讨SOX2在喉癌中的表达情况，并分析SOX2与临床因素的关系。
采用流式细胞仪（Epics-XL II）检测45例喉癌新鲜标本及45例癌旁组织（切缘>0.5 cm）中SOX2蛋白的表达，同时选取20例正常喉黏膜标本作为对照。
喉癌组织中SOX2蛋白的定量及定性表达分别明显高于癌旁组织和正常喉黏膜组织（P<0.05）。癌旁组织与正常喉黏膜组织的表达无明显差异。在喉癌中，SOX2蛋白的表达与患者的临床分型、肿瘤大小、吸烟史、患者年龄及性别无明显关系，但与转移、病理分级及临床分期有关。
SOX2的高表达可能促进喉癌的发生发展。检测SOX2蛋白的表达是判断喉癌转移、分期及预后的重要指标。
