Chung Amanda S J, Chabert Charles, Yap Hin-Wai, Lam Jimmy, Awad Nader, Nuwayhid Fadi, Redwig Frank, Rashid Prem, Woo Henry H
Sydney Adventist Hospital Clinical School, University of Sydney, Sydney, Australia.
ANZ J Surg. 2012 May;82(5):334-7. doi: 10.1111/j.1445-2197.2012.06038.x. Epub 2012 Mar 28.
Photoselective vaporization of the prostate (PVP) is widely used to treat benign prostatic obstruction (BPO), but there is little experience reported on the new more powerful 180W lithium triborate (LBO) laser. This study evaluates the safety and efficacy of using the 180W LBO laser to treat BPO by examining a multicentre Australian experience.
Retrospective review of prospectively collected data on all men treated by 180W LBO laser PVP by eight urologists across six Australian hospitals, from July 2011 to August 2011, was performed. Perioperative and functional outcomes were examined at baseline and 3 months.
Of the 85 men (median age 70 years, prostate volume 51 cm(3)) identified, 27% (23/85) were in urinary retention and 44% (37/85) were taking antiplatelet/anticoagulant medication. Median operating time was 46 min, laser time 27 min, energy use 211 kJ, post-operative duration of catheterization 15 h and hospitalization 22 h. Functional outcomes from baseline to 3 months, respectively, were for IPSS 25-7; QoL 5-2; Qmax 7.7-18.4; and PVR 147-38. All improvements were statistically significant (P < 0.01). Thirty-eight percent (32/85) of patients experienced at least one adverse event. Most adverse events were low Clavien-Dindo grade I-II. There were five grade III, two grade IV and no grade V adverse events. Sixty per cent (51/85) of men were able to be discharged home voiding successfully without a catheter within 24-h post-PVP.
Our early multicentre Australian experience indicates the 180W LBO laser PVP is an efficacious and safe treatment for BPO.
前列腺光选择性汽化术(PVP)被广泛用于治疗良性前列腺梗阻(BPO),但关于新型更强功率的180W硼酸锂(LBO)激光的应用经验报道较少。本研究通过考察澳大利亚多中心的经验,评估使用180W LBO激光治疗BPO的安全性和有效性。
对2011年7月至2011年8月期间澳大利亚六家医院的八位泌尿外科医生使用180W LBO激光PVP治疗的所有男性患者的前瞻性收集数据进行回顾性分析。在基线和3个月时检查围手术期和功能结局。
在确定的85名男性患者中(中位年龄70岁,前列腺体积51立方厘米),27%(23/85)处于尿潴留状态,44%(37/85)正在服用抗血小板/抗凝药物。中位手术时间为46分钟,激光照射时间为27分钟,能量使用为211千焦,术后导尿持续时间为15小时,住院时间为22小时。从基线到3个月的功能结局分别为:国际前列腺症状评分(IPSS)从25降至7;生活质量评分(QoL)从5降至2;最大尿流率(Qmax)从7.7增至18.4;残余尿量(PVR)从147降至38。所有改善均具有统计学意义(P < 0.01)。38%(32/85)的患者经历了至少一次不良事件。大多数不良事件为Clavien-Dindo低分级I-II级。有5例III级、2例IV级不良事件,无V级不良事件。60%(51/85)的男性患者在PVP术后24小时内能够成功排尿后不带导尿管出院回家。
我们澳大利亚早期多中心的经验表明,180W LBO激光PVP是一种治疗BPO有效且安全的方法。