Unité de Toxicologie Expérimentale, Institut National de l'Environnement Industriel et des Risques, Parc Technologique ALATA, BP no. 2, 60550 Verneuil-en-Halatte, France.
Exp Gerontol. 2012 Jun;47(6):444-51. doi: 10.1016/j.exger.2012.03.015. Epub 2012 Apr 6.
The widespread use of mobile phones raises the question of the effects of electromagnetic fields (EMF, 900 MHz) on the brain. Previous studies reported increased levels of the glial fibrillary acidic protein (GFAP) in the rat's brain after a single exposure to 900 MHz global system for mobile (GSM) signal, suggesting a potential inflammatory process. While this result was obtained in adult rats, no data is currently available in older animals. Since the transition from middle-age to senescence is highly dependent on environment and lifestyle, we studied the reactivity of middle-aged brains to EMF exposure. We assessed the effects of a single 15 min GSM exposure (900 MHz; specific absorption rate (SAR)=6 W/kg) on GFAP expression in young adults (6 week-old) and middle-aged rats (12 month-old). Brain interleukin (IL)-1β and IL-6, plasmatic levels of corticosterone (CORT), and emotional memory were also assessed. Our data indicated that, in contrast to previously published work, acute GSM exposure did not induce astrocyte activation. Our results showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, and increased plasmatic levels of CORT in GSM-exposed young adults. Altogether, our data showed an age dependency of reactivity to GSM exposure in neuro-immunity, stress and behavioral parameters. Reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters.
手机的广泛使用引发了一个问题，即电磁场（EMF，900MHz）对大脑的影响。先前的研究报告称，大鼠大脑在单次暴露于 900MHz 全球移动通信系统（GSM）信号后，神经胶质纤维酸性蛋白（GFAP）水平升高，表明存在潜在的炎症过程。虽然这一结果是在成年大鼠中获得的，但目前尚无老年动物的数据。由于从中年到老年的过渡高度依赖于环境和生活方式，我们研究了中年大脑对 EMF 暴露的反应性。我们评估了单次 15 分钟 GSM 暴露（900MHz；比吸收率（SAR）=6W/kg）对年轻成年（6 周龄）和中年大鼠（12 月龄）GFAP 表达的影响。还评估了脑内白细胞介素（IL）-1β和 IL-6、皮质酮（CORT）的血浆水平和情绪记忆。我们的数据表明，与之前发表的研究结果相反，急性 GSM 暴露不会诱导星形胶质细胞激活。我们的结果显示，GSM 暴露会增加嗅球中的 IL-1β，并增强中年大鼠的情境性情绪记忆，同时增加 GSM 暴露的年轻成年大鼠的血浆 CORT 水平。总的来说，我们的数据表明，在神经免疫、应激和行为参数方面，对 GSM 暴露的反应存在年龄依赖性。重现这些效应并研究其机制可能有助于更好地理解移动电话 EMF 对神经生物学参数的影响。
