Nittby Henrietta, Grafström Gustav, Tian Dong Ping, Malmgren Lars, Brun Arne, Persson Bertil R R, Salford Leif G, Eberhardt Jacob
Department of Neurosurgery, Lund University, The Rausing Laboratory and Lund University Hospital, Lund, Sweden.
Bioelectromagnetics. 2008 Apr;29(3):219-32. doi: 10.1002/bem.20386.
Considering the frequent use of mobile phones, we have directed attention to possible implications on cognitive functions. In this study we investigated in a rat model the long-term effects of protracted exposure to Global System for Mobile Communication-900 MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed for 2 h each week for 55 weeks to radio-frequency electromagnetic radiation at different SAR levels (0.6 and 60 mW/kg at the initiation of the experimental period) emitted by a (GSM-900) test phone. Sixteen animals were sham exposed and eight animals were cage controls, which never left the animal house. After this protracted exposure, GSM-900 exposed rats were compared to sham exposed controls. Effects on exploratory behaviour were evaluated in the open-field test, in which no difference was seen. Effects on cognitive functions were evaluated in the episodic-like memory test. In our study, GSM exposed rats had impaired memory for objects and their temporal order of presentation, compared to sham exposed controls (P = 0.02). Detecting the place in which an object was presented was not affected by GSM exposure. Our results suggest significantly reduced memory functions in rats after GSM microwave exposure (P = 0.02).
考虑到手机的频繁使用，我们已将注意力转向其对认知功能可能产生的影响。在本研究中，我们在大鼠模型中研究了长期暴露于全球移动通信系统900兆赫兹（GSM - 900）辐射的影响。在总共56只大鼠中，32只大鼠每周暴露2小时，持续55周，接受由一部（GSM - 900）测试手机发射的不同比吸收率（SAR）水平（实验期开始时为0.6和60毫瓦/千克）的射频电磁辐射。16只动物接受假暴露，8只动物作为笼养对照，它们从未离开动物房。经过这种长期暴露后，将暴露于GSM - 900的大鼠与假暴露对照组进行比较。在旷场试验中评估对探索行为的影响，未发现差异。在情景样记忆测试中评估对认知功能的影响。在我们的研究中，与假暴露对照组相比，暴露于GSM的大鼠对物体及其呈现的时间顺序的记忆受损（P = 0.02）。检测物体呈现的位置不受GSM暴露的影响。我们的结果表明，GSM微波暴露后大鼠的记忆功能显著降低（P = 0.02）。
