Dibaba D T, Xun P, Fly A D, Yokota K, He K
Department of Epidemiology and Biostatistics, School of Public Health--Bloomington, Indiana University, Bloomington, IN, USA.
Diabet Med. 2014 Nov;31(11):1301-9. doi: 10.1111/dme.12537.
To estimate quantitatively the association between dietary magnesium intake and risk of metabolic syndrome by combining the relevant published articles using meta-analysis.
We reviewed the relevant literature in PubMed and EMBASE published up until August 2013 and obtained additional information through Google or a hand search of the references in relevant articles. A random-effects or fixed-effects model, as appropriate, was used to pool the effect sizes on metabolic syndrome comparing individuals with the highest dietary magnesium intake with those having the lowest intake. The dose-response relationship was assessed for every 100-mg/day increment in magnesium intake and risk of metabolic syndrome.
Six cross-sectional studies, including a total of 24 473 individuals and 6311 cases of metabolic syndrome, were identified as eligible for the meta-analysis. A weighted inverse association was found between dietary magnesium intake and the risk of metabolic syndrome (odds ratio 0.69, 95% CI 0.59, 0.81) comparing the highest with the lowest group. For every 100-mg/day increment in magnesium intake, the overall risk of having metabolic syndrome was lowered by 17% (odds ratio 0.83, 95% CI 0. 77, 0.89).
Findings from the present meta-analysis suggest that dietary magnesium intake is inversely associated with the prevalence of metabolic syndrome. Further studies, in particular well-designed longitudinal cohort studies and randomized placebo-controlled clinical trials, are warranted to provide solid evidence and to establish causal inference.
通过对相关已发表文章进行荟萃分析，定量评估膳食镁摄入量与代谢综合征风险之间的关联。
我们检索了截至2013年8月在PubMed和EMBASE上发表的相关文献，并通过谷歌搜索或手工检索相关文章中的参考文献获取了更多信息。采用随机效应模型或固定效应模型（视情况而定），汇总比较膳食镁摄入量最高与最低的个体在代谢综合征方面的效应量。评估了镁摄入量每增加100毫克/天与代谢综合征风险之间的剂量反应关系。
六项横断面研究被确定符合荟萃分析的条件，这些研究共纳入24473名个体，其中有6311例代谢综合征患者。比较最高摄入量组与最低摄入量组发现，膳食镁摄入量与代谢综合征风险之间存在加权负相关（比值比为0.69，95%置信区间为0.59至0.81）。镁摄入量每增加100毫克/天，患代谢综合征的总体风险降低17%（比值比为0.83，95%置信区间为0.77至0.89）。
本荟萃分析的结果表明，膳食镁摄入量与代谢综合征的患病率呈负相关。有必要开展进一步的研究，尤其是设计良好的纵向队列研究和随机安慰剂对照临床试验，以提供确凿证据并建立因果推断。
