Key Laboratory of Environment Medicine and Engineering of Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu Province, China.
Wuxi City Center for Disease Control and Prevention, Jiangsu Province, Wuxi, Jiangsu Province, China.
Gene. 2021 Jun 5;784:145593. doi: 10.1016/j.gene.2021.145593. Epub 2021 Mar 23.
Obesity and metabolic syndrome frequently co-exist and define obese individuals into different obesity phenotypes, such as metabolically healthy obese (MHO), metabolically unhealthy obese (MUO) and metabolically unhealthy normal weight (MUNW). Growing evidence suggests that genetic predisposition and environmental factors can explain the heterogeneity among these phenotypes.
We conducted a case-control study including 130 MHO, 251 MUNW, 208 MUO and 336 health controls by genotyping 2 SNPs (rs2241766, rs1501299) in ADIPOQ to investigate possible associations between SNPs in the ADIPOQ gene with susceptibility to three obese phenotypes respectively in Chinese Han population. Unconditional logistic regressions were used to detect the association between ADIPOQ SNPs and MHO/MUNW/MUO risks.
Variant G allele of rs2241766 was associated with a reduced odds of MUO (additive model: Adjusted OR = 0.55; 95% CI = 0.40-0.75; P < 0.001) and no evidence of any significant association between rs2241766 and MHO phenotype (additive model: Adjusted OR = 0.84; 95% CI = 0.61-1.16; P = 0.306) or MUNW phenotype (additive model: Adjusted OR = 0.95; 95% CI = 0.73-1.24; P = 0.720) was found. Minor allele T of rs1501299 were significantly associated with decreased risk of MHO (Adjusted OR = 0.53; 95% CI = 0.37-0.76; P < 0.001) and MUNW (Adjusted OR = 0.63; 95% CI = 0.48-0.83; P = 0.001) in additive genetic model after correction for multiple testing.
The variant G allele of rs2241766 was negatively associated with risk of MUO and variant T allele of rs1501299 exhibited reduced odds for MHO and MUNW. Beyond that, future studies are warranted to validate and extend our findings.
肥胖症和代谢综合征经常同时存在，并将肥胖个体定义为不同的肥胖表型，如代谢健康型肥胖（MHO）、代谢不健康型肥胖（MUO）和代谢不健康型正常体重（MUNW）。越来越多的证据表明，遗传倾向和环境因素可以解释这些表型之间的异质性。
我们通过对 ADIPOQ 基因中的 2 个 SNP（rs2241766、rs1501299）进行基因分型，对 130 名 MHO、251 名 MUNW、208 名 MUO 和 336 名健康对照进行了病例对照研究，以探讨 ADIPOQ 基因中的 SNP 与中国汉族人群中三种肥胖表型的易感性之间的可能关联。采用非条件逻辑回归检测 ADIPOQ SNPs 与 MHO/MUNW/MUO 风险之间的关联。
rs2241766 的变异 G 等位基因与 MUO 的患病风险降低相关（加性模型：调整后的 OR=0.55；95%CI=0.40-0.75；P<0.001），而 rs2241766 与 MHO 表型（加性模型：调整后的 OR=0.84；95%CI=0.61-1.16；P=0.306）或 MUNW 表型（加性模型：调整后的 OR=0.95；95%CI=0.73-1.24；P=0.720）之间没有明显的关联。rs1501299 的次要等位基因 T 与 MHO（调整后的 OR=0.53；95%CI=0.37-0.76；P<0.001）和 MUNW（调整后的 OR=0.63；95%CI=0.48-0.83；P=0.001）的患病风险降低显著相关，且经过多重检验校正后。
rs2241766 的变异 G 等位基因与 MUO 的患病风险呈负相关，rs1501299 的变异 T 等位基因与 MHO 和 MUNW 的患病风险降低相关。除此之外，还需要进一步的研究来验证和扩展我们的发现。
