将脐带血捐献给公共血库或存放在私人血库：献血者和孕妇的知识和偏好。
Donating umbilical cord blood to a public bank or storing it in a private bank: knowledge and preference of blood donors and of pregnant women.
机构信息
Unit of Immunohaematology and Transfusion Medicine, Umberto I Polyclinic Hospital, Rome, Italy.
出版信息
Blood Transfus. 2012 Jul;10(3):331-7. doi: 10.2450/2012.0081-11. Epub 2012 Mar 28.
BACKGROUND
Umbilical cord blood (UCB) is a source of stem cells for allogeneic haematopoietic transplantation in paediatric and adult patients with haematological malignancies and other indications. Voluntary donation is the basis for the success of unrelated UCB transplantation programmes. In the last few years a growing number of private banks offer their services to expectant parents, to store UCB for future use. The debate concerning UCB donation and private preservation has been ongoing for several years. The aims of this single centre study were to explore knowledge about UCB stem cells and attitudes towards voluntary UCB donation or private UCB preservation among both blood donors and pregnant women.
MATERIALS AND METHODS
This study was conducted at the "Sapienza" University of Rome. Two types of anonymous questionnaires were prepared: one type was administered to 1,000 blood donors while the other type was distributed to 300 pregnant women.
RESULTS
Most blood donors as well as the majority of pregnant women had some general knowledge about UCB (89% and 93%, respectively) and were aware of the possibility of donating it (82% and 95%). However, the level of knowledge regarding current therapeutic use resulted generally low, only 91 (10%) among informed blood donors and 69 (31%) among informed pregnant women gave a correct answer. The survey revealed a preference for voluntary donation both among blood donors (76%) and among pregnant woman (55%). Indeed, a minority of blood donors (6.5%) and of pregnant women (9%) would opt to store UCB for private use.
DISCUSSION
The study raises the following considerations: (i) the large support for UCB donation expressed by blood donors and by pregnant women suggests that UCB preservation does not represent an obstacle to the expansion of UCB donation and to development of unrelated transplantation programmes; (ii) information about UCB donation and preservation should be carefully given by professionals and institutions.
背景
脐带血（UCB）是儿科和成年血液系统恶性肿瘤和其他适应证患者异基因造血移植的干细胞来源。自愿捐献是无关 UCB 移植项目成功的基础。在过去的几年中，越来越多的私人银行向准父母提供服务，为将来使用而储存 UCB。关于 UCB 捐献和私人保存的争论已经持续了几年。本单中心研究的目的是探讨血液捐献者和孕妇对 UCB 干细胞的认识以及对自愿 UCB 捐献或私人 UCB 保存的态度。
材料和方法
该研究在罗马“萨皮恩扎”大学进行。准备了两种类型的匿名问卷：一种类型发放给 1000 名献血者，另一种类型分发给 300 名孕妇。
结果
大多数献血者和大多数孕妇对 UCB 有一定的一般认识（分别为 89%和 93%），并意识到捐献的可能性（分别为 82%和 95%）。然而，关于当前治疗用途的知识水平普遍较低，只有 91 名（10%）知情献血者和 69 名（31%）知情孕妇给出了正确答案。调查显示，献血者（76%）和孕妇（55%）都更倾向于自愿捐献。事实上，少数献血者（6.5%）和孕妇（9%）会选择为私人用途储存 UCB。
讨论
该研究提出了以下几点考虑：（i）献血者和孕妇对 UCB 捐献的大力支持表明，UCB 保存不会成为 UCB 捐献扩大和无关移植项目发展的障碍；（ii）专业人员和机构应仔细提供有关 UCB 捐献和保存的信息。
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