Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Medical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.
PLoS One. 2023 Oct 24;18(10):e0293366. doi: 10.1371/journal.pone.0293366. eCollection 2023.
Studies have shown the possibility of using the part of the foreskin removed after circumcision in the field of scientific and therapeutic research. Donations of tissues and organs are always associated with ethical challenges posed by bioethicists and societies to ensure the appropriate use of these tissues/organs. The purpose of this study was to understand the attitudes and awareness of parents/guardians regarding donation of excised foreskin to research and medical use. The study was based on a questionnaire and included 133 parents/guardians who visited Uhud Children's Hospital in Madinah, Saudi Arabia for newborn male circumcision. The results showed a high willingness (61.7%) to donate the extracted foreskin to research. The willingness to donate the extracted foreskin to research associated with undergraduate degree (P = 0.018), male sex (P = 0.011), high income (P = 0.029), and participation in previous research studies (P = 0.002). About 41.8% were convinced that written informed consent should be obtained before circumcision surgery, 38.1% (n = 51) were convinced that written informed consent should be taken after surgery, while the remaining 19.4% reported that the timing of written informed consent is unimportant. Finally, fear of excision of excess tissue (74.5%), lack of confidence in the research (68.6%), and potential for commercial use (64.7%) were the main barriers to unwillingness to donate the excised foreskin for research. In conclusion, a reasonable portion of Saudis agreed to donate their foreskin for research purposes. There is an urgent need to enhance awareness and attitudes towards tissue donation for research and therapeutic use.
研究表明，在科学和治疗研究领域，可以使用割礼切除的包皮的一部分。组织和器官的捐赠总是与生物伦理学家和社会提出的伦理挑战相关联，以确保这些组织/器官的合理使用。本研究旨在了解父母/监护人对捐赠割礼后包皮用于研究和医疗用途的态度和意识。该研究基于问卷，共纳入 133 名在沙特阿拉伯麦地那乌胡德儿童医院为新生儿行男性割礼的父母/监护人。结果显示，他们非常愿意（61.7%）将提取的包皮捐赠用于研究。愿意将提取的包皮捐赠用于研究与本科以上学历（P=0.018）、男性（P=0.011）、高收入（P=0.029）和参与先前研究（P=0.002）相关。约 41.8%的人认为应该在包皮环切术前获得书面知情同意，38.1%（n=51）认为应该在手术后获得书面知情同意，而其余 19.4%的人报告说书面知情同意的时间并不重要。最后，不愿为研究捐赠割礼后的包皮主要是因为担心切除多余组织（74.5%）、对研究缺乏信心（68.6%）和潜在的商业用途（64.7%）。总之，相当一部分沙特人同意将其包皮捐赠用于研究目的。迫切需要提高对组织捐赠用于研究和治疗用途的认识和态度。
