真正的衰老 Sirtuin 蛋白请站出来？
Will the real aging Sirtuin please stand up?
机构信息
Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.
出版信息
Cell Res. 2012 Aug;22(8):1215-7. doi: 10.1038/cr.2012.62. Epub 2012 Apr 17.
Abstract
Initial studies linking Sirtuins to longevity in yeast initiated what is now a rich vein of aging research that is full of promise and fraught with controversy. Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals. Now Kanfi et al. provide the evidence but with an interesting plot twist - the lesser known SIRT6 is the longevity factor.
摘要
最初的研究将 Sirtuins 与酵母的长寿联系起来，这开创了丰富的衰老研究领域，其中充满了希望，但也充满了争议。目前缺少的是增强 Sirtuins 表达是否能延长哺乳动物寿命的证明。现在，Kanfi 等人提供了证据，但情节却很曲折——不太知名的 SIRT6 才是长寿因子。
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