Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, 43210, USA.
Philos Trans A Math Phys Eng Sci. 2012 May 28;370(1967):2269-303. doi: 10.1098/rsta.2011.0498.
Biosensors are a broad array of devices that detect the type and amount of a biological species or biomolecule. Several different types of biosensors have been developed that rely on changes to mechanical, chemical or electrical properties of the transduction or sensing element to induce a measurable signal. Often, a biosensor will integrate several functions or unit operations such as sample extraction, manipulation and detection on a single platform. This review begins with an overview of the current state-of-the-art biosensor field. Next, the review delves into a special class of biosensors that rely on microfluidics and nanofluidics by presenting the underlying theory, fabrication and several examples and applications of microfluidic and nanofluidic sensors.
生物传感器是一类广泛的设备，用于检测生物物种或生物分子的类型和数量。已经开发出几种不同类型的生物传感器，它们依赖于转换或传感元件的机械、化学或电气特性的变化来产生可测量的信号。通常，生物传感器将在单个平台上集成多个功能或单元操作，例如样品提取、操作和检测。本综述首先概述了当前生物传感器领域的最新技术。接下来，通过介绍微流控和纳流控的基本理论、制造以及微流控和纳流控传感器的几个示例和应用，深入探讨了一类特殊的依赖于微流控和纳流控的生物传感器。
