Yin Binfeng, Wan Xinhua, Sohan A S M Muhtasim Fuad, Lin Xiaodong
School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China.
College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China.
Micromachines (Basel). 2022 Aug 1;13(8):1238. doi: 10.3390/mi13081238.
A microfluidic chip is a tiny reactor that can confine and flow a specific amount of fluid into channels of tens to thousands of microns as needed and can precisely control fluid flow, pressure, temperature, etc. Point-of-care testing (POCT) requires small equipment, has short testing cycles, and controls the process, allowing single or multiple laboratory facilities to simultaneously analyze biological samples and diagnose infectious diseases. In general, rapid detection and stage assessment of viral epidemics are essential to overcome pandemic situations and diagnose promptly. Therefore, combining microfluidic devices with POCT improves detection efficiency and convenience for viral disease SARS-CoV-2. At the same time, the POCT of microfluidic chips increases user accessibility, improves accuracy and sensitivity, shortens detection time, etc., which are beneficial in detecting SARS-CoV-2. This review shares recent advances in POCT-based testing for COVID-19 and how it is better suited to help diagnose in response to the ongoing pandemic.
微流控芯片是一种微型反应器，它能够根据需要将特定量的流体限制并流入几十到几千微米的通道中，并且可以精确控制流体流动、压力、温度等。即时检测（POCT）设备体积小、检测周期短且能控制检测过程，允许单个或多个实验室设施同时分析生物样本并诊断传染病。一般来说，对病毒流行进行快速检测和阶段评估对于克服大流行情况和及时诊断至关重要。因此，将微流控设备与即时检测相结合可提高对病毒性疾病严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的检测效率和便利性。同时，微流控芯片的即时检测增加了用户可及性，提高了准确性和灵敏度，缩短了检测时间等，这些都有利于检测SARS-CoV-2。本综述分享了基于即时检测的2019冠状病毒病（COVID-19）检测的最新进展，以及它如何更适合于帮助应对当前的大流行进行诊断。
