非遗传性细胞变异性加速了癌症的进化过程。
Nonheritable cellular variability accelerates the evolutionary processes of cancer.
机构信息
Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America.
出版信息
PLoS Biol. 2012;10(4):e1001296. doi: 10.1371/journal.pbio.1001296. Epub 2012 Apr 3.
Abstract
Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy.
摘要
最近的癌症研究强调，遗传和可遗传的表观遗传变化推动了癌症进展和耐药性的进化速度。我们讨论了细胞变异性的非遗传方面如何显著增加进化速度。非遗传变异性是由细胞的随机波动和细胞对环境的生理反应引起的。可能需要新的药物设计方法来控制非遗传变异性和化疗耐药性的演变。
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本文引用的文献
1
Clonal evolution in cancer.癌症中的克隆进化。
Nature. 2012 Jan 18;481(7381):306-13. doi: 10.1038/nature10762.
2
Natural selection. II. Developmental variability and evolutionary rate.自然选择。二、发育变异性与进化率。
J Evol Biol. 2011 Nov;24(11):2310-20. doi: 10.1111/j.1420-9101.2011.02373.x. Epub 2011 Sep 21.
3
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.随机状态转变导致癌细胞群体中的表型平衡。
Cell. 2011 Aug 19;146(4):633-44. doi: 10.1016/j.cell.2011.07.026.
4
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.基于进化癌症建模的 EGFR 突变型非小细胞肺癌给药优化。
Sci Transl Med. 2011 Jul 6;3(90):90ra59. doi: 10.1126/scitranslmed.3002356.
5
A history of phenotypic plasticity accelerates adaptation to a new environment.表型可塑性的历史加速了对新环境的适应。
J Evol Biol. 2011 Sep;24(9):1992-2001. doi: 10.1111/j.1420-9101.2011.02333.x. Epub 2011 Jun 8.
6
Characterization of stem cells and cancer cells on the basis of gene expression profile stability, plasticity, and robustness: dynamical systems theory of gene expressions under cell-cell interaction explains mutational robustness of differentiated cells and suggests how cancer cells emerge.基于基因表达谱稳定性、可塑性和鲁棒性对干细胞和癌细胞进行表征：细胞间相互作用下基因表达的动力学系统理论解释了分化细胞的突变鲁棒性，并提出了癌细胞是如何出现的。
Bioessays. 2011 Jun;33(6):403-13. doi: 10.1002/bies.201000153. Epub 2011 May 2.
7
Hallmarks of cancer: the next generation.癌症的特征：下一代。
Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
8
Dissecting variability in responses to cancer chemotherapy through systems pharmacology.通过系统药理学解析癌症化疗反应的可变性。
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9
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.持续肿瘤生长需要暂时存在的慢循环黑素瘤细胞亚群。
Cell. 2010 May 14;141(4):583-94. doi: 10.1016/j.cell.2010.04.020.
10
Cellular heterogeneity: do differences make a difference?细胞异质性：差异是否有影响？
Cell. 2010 May 14;141(4):559-63. doi: 10.1016/j.cell.2010.04.033.
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