Department of Chemistry, Faculty of Science for Girls, King Abdulaziz University, Jeddah, P.O. Box 50918, Jeddah 21533, Saudi Arabia.
J Med Chem. 2012 May 10;55(9):4169-77. doi: 10.1021/jm2014315. Epub 2012 Apr 26.
In this paper we report the synthesis of some novel 1,2,4-triazolo[1,5-a]pyridine and azolotriazolopyridine ring systems. The products were screened for various types of activity like antibacterial, antifungal, and antioxidative activity. Compound 13 was found to pose an antioxidative activity. In addition, this compound was found to extend the life span of Caenorhabiditis elegans under standard laboratory conditions and reduces both heat and chemical induced oxidative stress in C. elegans in a dose-dependent manner. Furthermore, treatment of worms with compound 13 was found to significantly attenuate the formation of advanced glycation end products and malondialdehyde in a dose-dependent manner.
在本文中，我们报告了一些新型 1,2,4-三唑并[1,5-a]嘧啶和氮杂三唑并吡啶环系统的合成。对这些产物进行了各种类型的活性筛选，如抗菌、抗真菌和抗氧化活性。发现化合物 13 具有抗氧化活性。此外，该化合物还被发现可以延长秀丽隐杆线虫在标准实验室条件下的寿命，并以剂量依赖的方式降低秀丽隐杆线虫的热应激和化学诱导氧化应激。此外，用化合物 13 处理蠕虫可显著减轻高级糖基化终产物和丙二醛的形成，且呈剂量依赖性。
