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来自 Roscoe 的 6-姜酚的长寿和抗应激特性 。 你提供的原文似乎不太完整，“in.”后面应该还有具体内容。

Longevity and Stress Resistant Property of 6-Gingerol from Roscoe in .

作者信息

Lee Eun Byeol, Kim Jun Hyeong, An Chang Wan, Kim Yeong Jee, Noh Yun Jeong, Kim Su Jin, Kim Ju-Eun, Shrestha Abinash Chandra, Ham Ha-Neul, Leem Jae-Yoon, Jo Hyung-Kwon, Kim Dae-Sung, Moon Kwang Hyun, Lee Jeong Ho, Jeong Kyung Ok, Kim Dae Keun

机构信息

College of Pharmacy, Woosuk University, Jeonju 55338, Republic of Korea.

Hanpoong Pharm. Co., LTD, Wanju 55336, Republic of Korea.

出版信息

Biomol Ther (Seoul). 2018 Nov 1;26(6):568-575. doi: 10.4062/biomolther.2017.215.

DOI:10.4062/biomolther.2017.215
PMID:29534560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6254644/
Abstract

In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Roscoe (Zingiberaceae) ethanol extract was performed using the () model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of , and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.

摘要

为了发现由自然资源制成的寿命延长化合物，使用（）模型系统对山姜属（姜科）乙醇提取物进行了活性导向分级分离。从活性最强的乙酸乙酯可溶级分中分离出化合物6-姜酚，其显示出强大的促长寿活性。它还提高了蠕虫在包括热、渗透和氧化条件在内的应激环境下的存活率。此外，6-姜酚提高了（）的抗氧化酶活性，并显示出蠕虫细胞内活性氧（ROS）积累的剂量依赖性降低。进一步的研究表明，6-姜酚介导的蠕虫应激耐受性增加可能是由于促进了应激抗性蛋白，如热休克蛋白（HSP-16.2）和超氧化物歧化酶（SOD-3）。与对照组相比，6-姜酚处理的肠道蠕虫中的脂褐素水平降低。未观察到与6-姜酚相关的显著变化，包括生长、食物摄入、繁殖和运动。这些结果表明，6-姜酚独立于这些因素发挥促长寿活性，并可能延长人类寿命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/acbc46fe2aaa/bt-26-568f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/265671bb8a79/bt-26-568f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/342a7b369094/bt-26-568f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/5b16a147e7b1/bt-26-568f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/a9d3c649a71c/bt-26-568f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/c1b16c6f2285/bt-26-568f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/9188ef0731f4/bt-26-568f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/acbc46fe2aaa/bt-26-568f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/265671bb8a79/bt-26-568f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/342a7b369094/bt-26-568f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/5b16a147e7b1/bt-26-568f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/a9d3c649a71c/bt-26-568f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/c1b16c6f2285/bt-26-568f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/9188ef0731f4/bt-26-568f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0826/6254644/acbc46fe2aaa/bt-26-568f7.jpg

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