Centre de recherche, Institut Universitaire de cardiologie et de pneumologie de Québec, Université Laval, Canada.
COPD. 2012 Aug;9(4):395-400. doi: 10.3109/15412555.2012.674164. Epub 2012 Apr 18.
We examined the responsiveness of a 3-minute constant rate shuttle walking protocol to detect improvements in exertional dyspnea following acute bronchodilation in COPD. Our hypothesis was that the 3-minute constant rate shuttle walking protocol would be able to adequately put forth improvements in exertional dyspnea following acute bronchodilation in this population.
Using a placebo controlled, double-blind cross-over design, 39 patients with moderate to severe COPD performed a 3-min constant rate shuttle walking test during which they were asked to walk on a flat corridor at a speed that was externally imposed by an audio signal. During the test, dyspnea was graded using the 10-point modified Borg scale. The test was performed twice, following the administration of saline placebo or of 500 μg nebulized ipratropium bromide.
Improvements of respiratory pattern (respiratory rate and tidal volume) and statistically and clinically significant reductions in Borg dyspnea scores (∆ dyspnea score = 1.0 ± 0.2, p < 0.01) were seen during the 3-min shuttle walking protocol with ipratropium bromide compared to placebo.
This 3-minute shuttle walking protocol adequately detected dyspnea and breathing pattern improvements following acute bronchodilation in COPD.
我们研究了 3 分钟恒速穿梭步行方案的反应能力，以检测 COPD 急性支气管扩张后运动性呼吸困难的改善情况。我们的假设是，3 分钟恒速穿梭步行方案能够充分改善该人群急性支气管扩张后运动性呼吸困难。
采用安慰剂对照、双盲交叉设计，39 例中重度 COPD 患者进行 3 分钟恒速穿梭步行测试，要求他们在平坦的走廊上以外部音频信号强制的速度行走。在测试过程中，使用 10 点改良 Borg 量表对呼吸困难进行分级。该测试进行了两次，分别在给予生理盐水安慰剂或 500μg 雾化异丙托溴铵后进行。
与安慰剂相比，异丙托溴铵组在 3 分钟穿梭步行方案中呼吸模式（呼吸频率和潮气量）得到改善，且 Borg 呼吸困难评分有统计学和临床意义的降低（∆呼吸困难评分=1.0±0.2，p<0.01）。
本 3 分钟穿梭步行方案充分检测到 COPD 急性支气管扩张后呼吸困难和呼吸模式的改善。
